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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Cell-surface heparan sulfate proteoglycans are essential components of the unconventional export machinery of FGF-2.

FGF-2 is an unconventionally secreted lectin that transmits proangiogenic signals through a ternary complex with high-affinity FGF receptors and heparan sulfate proteoglycans (HSPGs). Although FGF-2 signal transduction is understood in great detail, its mechanism of release from cells, which is independent of the classical secretory pathway, remains elusive. To test the hypothesis that FGF-2 secretion is linked to its cell-surface ligands, we studied FGF-2 release using mutants defective for HSPG binding and cells with impaired HSPG biosynthesis. Here, we report that a functional interaction between FGF-2 and HSPGs is required for net export of FGF-2 from mammalian cells. FGF-2 release requires extracellular, membrane-proximal HSPGs. We propose that extracellular HSPGs form a molecular trap that drives FGF-2 translocation across the plasma membrane.[1]

References

  1. Cell-surface heparan sulfate proteoglycans are essential components of the unconventional export machinery of FGF-2. Zehe, C., Engling, A., Wegehingel, S., Sch??fer, T., Nickel, W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
 
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