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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Life and death of the distal nephron: WNK4 and NCC as major players.

Missense mutations in the WNK4 gene lead to the development of familial hyperkalemic hypertension, a rare form of human hypertension. It was shown in vitro that WNK4 regulates the surface expression and activity of a number of ion channels and transporters. The in vivo analysis of wild-type and mutant WNK4 overexpression in transgenic mice models demonstrated that this serine-threonine kinase controls ion handling in the kidney mainly, and probably exclusively, through the regulation of the Na-Cl contransporter NCC activity.[1]

References

  1. Life and death of the distal nephron: WNK4 and NCC as major players. Hadchouel, J., Jeunemaitre, X. Cell metabolism (2006) [Pubmed]
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