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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Herpesvirus antibodies and antigens in patients with cervical anaplasia and in controls.

Antibody activity to herpesvirus hominis type 2 (HVH-2) in 151 women cured of cervical carcinoma (60 in situ, 91 invasive) and in 106 controls differed significantly, especially between the in situ (73%) and control (17%) groups. Sera of 57 patients with cervical atypia showed an increased antibody activity to HVH-2 (58%), compared with that of the 57 matched controls (23%). Antibodies to cytomegalovirus (CMV) were detected more frequently in sera of women with atypia (61%) than in sera of women with cervical disorders other than atypia (42%) or in sera of healthy controls (33%). HVH antigens were present in cervical cells from patients with atypia and from matched controls. Not only exfoliated (imprints) but also cultured and cocultured cervical cells contained HVH antigens; there was no correlation between antigen positivity and antibody activity to HVH-2. Our data further supported the association between HVH-2 and cervical anaplasia and indicated that CMV may also be implicated in its etiology.[1]


  1. Herpesvirus antibodies and antigens in patients with cervical anaplasia and in controls. Pacsa, A.S., Kummerländer, L., Pejtsik, B., Pali, K. J. Natl. Cancer Inst. (1975) [Pubmed]
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