The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Simplexvirus


Psychiatry related information on Simplexvirus


High impact information on Simplexvirus


Chemical compound and disease context of Simplexvirus


Anatomical context of Simplexvirus


Gene context of Simplexvirus

  • Murine fibroblast-derived VPC expressing herpes-simplex-virus type I thymidine kinase (HSV-tk) were genetically modified to co-express a human Fas ligand (CD95L) deletion mutant (DeltaFasL) resistant to enzymatic cleavage and shedding [17].
  • Herpesvirus papio 2 encodes a virion host shutoff function [18].
  • Sera were obtained from 985 patients for detection of Type I and II herpesvirus hominis antibodies [19].
  • Conversely, D.S.500 increased the resistance of mice to another group of herpes simplex-viruses (strains D-316, Thea, DD), if given 3 to 8 hours before infection [20].
  • We have sequenced the thymidine kinase gene of a canine herpesvirus, and with a multiple alignment have identified amino acids preferentially conserved in either of two taxons, the genera Varicellovirus and Simplexvirus, of the subfamily Alphaherpesvirinae [21].

Analytical, diagnostic and therapeutic context of Simplexvirus


  1. Synergistic antiviral effects of adenine arabinoside and humoral antibodies in experimental encephalitis due to Herpesvirus hominis. Cho, C.T., Feng, K.K., Brahmacupta, N. J. Infect. Dis. (1976) [Pubmed]
  2. Escherichia coli and herpes-simplex-virus ribonucleotide reductase R2 subunit. Compared reactivities of the redox centres. Atta, M., Lamarche, N., Battioni, J.P., Massie, B., Langelier, Y., Mansuy, D., Fontecave, M. Biochem. J. (1993) [Pubmed]
  3. Antiviral activity of adenine arabinoside and iododeoxyuridine in human fetal intestinal and tracheal organ cultures. Dolin, R., Smith, H.A. J. Infect. Dis. (1975) [Pubmed]
  4. Prospects for herpes-simplex-virus thymidine-kinase and cytokine gene transduction as immunomodulatory gene therapy for prostate cancer. Hassan, W., Sanford, M.A., Woo, S.L., Chen, S.H., Hall, S.J. World journal of urology. (2000) [Pubmed]
  5. Latent herpesvirus hominis 1 in the central nervous system of psychotic patients. Libíková, H., Pogády, J., Rajcáni, J., Skodácek, I., Ciampor, F., Kocisová, M. Acta Virol. (1979) [Pubmed]
  6. Acyclovir prophylaxis of herpes-simplex-virus infections. Saral, R., Burns, W.H., Laskin, O.L., Santos, G.W., Lietman, P.S. N. Engl. J. Med. (1981) [Pubmed]
  7. Herpesvirus antibodies and antigens in patients with cervical anaplasia and in controls. Pacsa, A.S., Kummerländer, L., Pejtsik, B., Pali, K. J. Natl. Cancer Inst. (1975) [Pubmed]
  8. Effect of adenine arabinoside on severe Herpesvirus hominis infections in man. 1973. Ch'ien, L.T., Cannon, N.J., Charamella, L.J., Dismukes, W.E., Whitley, R.J., Buchanan, R.A., Alford, C.A. J. Infect. Dis. (2004) [Pubmed]
  9. Commentary: Ch'ien LT, Cannon NJ, Charamella LJ, et al. effect of adenine arabinoside on severe herpesvirus hominis infections in man: preliminary report. J Infect Dis 1973; 128:658-63. Whitley, R.J. J. Infect. Dis. (2004) [Pubmed]
  10. Effect of treatment with exogenous interferon, polyriboinosinic-polyribocytidylic acid, or polyriboinosinic-polyribocytidylic acid-poly-L-lysine complex on Herpesvirus hominis infections in mice. Olsen, G.A., Kern, E.R., Overall, J.C. J. Infect. Dis. (1978) [Pubmed]
  11. Alteration of mortality and pathogenesis of three experimental Herpesvirus hominis infections of mice with adenine arabinoside 5'-monophosphate, adenine arabinoside, and phosphonoacetic acid. Kern, E.R., Richards, J.T., Overall, J.C., Glasgow, L.A. Antimicrob. Agents Chemother. (1978) [Pubmed]
  12. Herpesvirus hominis infection in newborn mice: treatment with interferon inducer polyinosinic-polycytidylic acid. Kern, E.R., Overall, J.C., Glasgow, L.A. Antimicrob. Agents Chemother. (1975) [Pubmed]
  13. Interferon induction by radioprotective mercaptoalkylamines and derived thiophosphates. Lvovsky, E., Levy, H.B., Doherty, D.G., Baron, S. Infect. Immun. (1977) [Pubmed]
  14. In vitro activity of silver sulfadiazine against Herpesvirus hominis. Chang T-W, n.u.l.l., Weinstein, L. J. Infect. Dis. (1975) [Pubmed]
  15. Herpesvirus hominis infection in newborn mice: comparison of the therapeutic efficacy of 1-beta-D-arabinofuranosylcytosine and 9-beta-D-arabinofuranosyladenine. Kern, E.R., Overall, J.C., Glasgow, L.A. Antimicrob. Agents Chemother. (1975) [Pubmed]
  16. Thymidine kinase activity in cerebrospinal fluid of rabbits with Herpesvirus hominis encephalitis. Hilty, M.D., Thomas, D.C., Haynes, R.E., Cramblett, H.G. Pediatr. Res. (1975) [Pubmed]
  17. Expression of mutant non-cleavable Fas ligand on retrovirus packaging cells causes apoptosis of immunocompetent cells and improves prodrug activation gene therapy in a malignant glioma model. Nafe, C., Cao, Y.J., Quinones, A., Dobberstein, K.U., Kramm, C.M., Rainov, N.G. Life Sci. (2003) [Pubmed]
  18. Herpesvirus papio 2 encodes a virion host shutoff function. Bigger, J.E., Martin, D.W. Virology (2002) [Pubmed]
  19. Herpesvirus hominis type II infections in asymptomatic pregnant women. Bolognese, R.J., Corson, S.L., Fuccillo, D.A., Traub, R., Moder, F., Sever, J.L. Obstetrics and gynecology. (1976) [Pubmed]
  20. The effect of dextransulfate 500 on the pathogenesis of herpes simplex virus infections in weanling mice. Frank, U., Caspary, L., Hahn, H., Falke, D. Arch. Virol. (1978) [Pubmed]
  21. Sequence of the canine herpesvirus thymidine kinase gene: taxon-preferred amino acid residues in the alphaherpesviral thymidine kinases. Rémond, M., Sheldrick, P., Lebreton, F., Foulon, T. Virus Res. (1995) [Pubmed]
  22. Early and delayed skin reactivity to solubilized antigens of herpesvirus hominis 1 in psychiatric patients and guinea pigs. Libíková, H., Pogády, J., Kutinová, L., Breier, S., Matis, J. Acta Virol. (1980) [Pubmed]
  23. Detection of primate herpesvirus antibodies including Herpesvirus simiae by enzyme immunoassay. Eichberg, J.W., Heberling, R.L., Guajardo, J.E., Kalter, S.S. Dev. Biol. Stand. (1980) [Pubmed]
WikiGenes - Universities