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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Enzymatic Formation of Quinolone Alkaloids by a Plant Type III Polyketide Synthase.

Benzalacetone synthase from Rheum palmatum efficiently catalyzed condensation of N-methylanthraniloyl-CoA (or anthraniloyl-CoA) with malonyl-CoA (or methylmalonyl-CoA) to produce 4-hydroxy-2(1H)-quinolones, a novel alkaloidal scaffold produced by a type III polyketide synthase (PKS). Manipulation of the functionally divergent type III PKSs by a nonphysiological substrate thus provides an efficient method for production of pharmaceutically important quinolone alkaloids.[1]

References

  1. Enzymatic Formation of Quinolone Alkaloids by a Plant Type III Polyketide Synthase. Abe, I., Abe, T., Wanibuchi, K., Noguchi, H. Org. Lett. (2006) [Pubmed]
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