Chemical Compound Review:
Malonyl CoA 2-[2-[3-[[4-[[[(2R,3S,4R,5R)- 5-(6...
Synonyms:
malonyl-CoA, HMDB01175, AC1L1VOH, AC1Q5V7Q, 524-14-1, ...
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- Hypothalamic malonyl-CoA as a mediator of feeding behavior. Hu, Z., Cha, S.H., Chohnan, S., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values. Cook, G.A. J. Biol. Chem. (1984)
- A new pathway for polyketide synthesis in microorganisms. Funa, N., Ohnishi, Y., Fujii, I., Shibuya, M., Ebizuka, Y., Horinouchi, S. Nature (1999)
- Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Abu-Elheiga, L., Matzuk, M.M., Abo-Hashema, K.A., Wakil, S.J. Science (2001)
- Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Loftus, T.M., Jaworsky, D.E., Frehywot, G.L., Townsend, C.A., Ronnett, G.V., Lane, M.D., Kuhajda, F.P. Science (2000)
- C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Thupari, J.N., Landree, L.E., Ronnett, G.V., Kuhajda, F.P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell. Roduit, R., Morin, J., Massé, F., Segall, L., Roche, E., Newgard, C.B., Assimacopoulos-Jeannet, F., Prentki, M. J. Biol. Chem. (2000)
- Evidence that two covalent intermediates, phosphoryl and malonyl enzymes, are formed during malonyl-coenzyme A synthetase catalysis. Kim, Y.S., Lee, J.K. J. Biol. Chem. (1986)
- Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Prentki, M., Corkey, B.E. Diabetes (1996)
- Mycobacterium smegmatis fatty acid synthetase. A mechanism based on steady state rates and product distributions. Wood, W.I., Peterson, D.O., Bloch, K. J. Biol. Chem. (1977)
- Molecular disruption of hypothalamic nutrient sensing induces obesity. He, W., Lam, T.K., Obici, S., Rossetti, L. Nat. Neurosci. (2006)
- AMPK, the metabolic syndrome and cancer. Luo, Z., Saha, A.K., Xiang, X., Ruderman, N.B. Trends Pharmacol. Sci. (2005)
- Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. Cha, S.H., Hu, Z., Chohnan, S., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. Jez, J.M., Bowman, M.E., Noel, J.P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Wolfgang, M.J., Kurama, T., Dai, Y., Suwa, A., Asaumi, M., Matsumoto, S., Cha, S.H., Shimokawa, T., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Complex nested promoters control tissue-specific expression of acetyl-CoA carboxylase genes in wheat. Zuther, E., Huang, S., Jelenska, J., Eilenberg, H., Arnold, E.M., Su, X., Sirikhachornkit, A., Podkowinski, J., Zilberstein, A., Haselkorn, R., Gornicki, P. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1{alpha}. Cha, S.H., Rodgers, J.T., Puigserver, P., Chohnan, S., Lane, M.D. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The subcellular localization of acetyl-CoA carboxylase 2. Abu-Elheiga, L., Brinkley, W.R., Zhong, L., Chirala, S.S., Woldegiorgis, G., Wakil, S.J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity. Jayakumar, A., Chirala, S.S., Wakil, S.J. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Mao, J., DeMayo, F.J., Li, H., Abu-Elheiga, L., Gu, Z., Shaikenov, T.E., Kordari, P., Chirala, S.S., Heird, W.C., Wakil, S.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. Jain, M., Petzold, C.J., Schelle, M.W., Leavell, M.D., Mougous, J.D., Bertozzi, C.R., Leary, J.A., Cox, J.S. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae. Kohlwein, S.D., Eder, S., Oh, C.S., Martin, C.E., Gable, K., Bacikova, D., Dunn, T. Mol. Cell. Biol. (2001)
- RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. Brusselmans, K., De Schrijver, E., Verhoeven, G., Swinnen, J.V. Cancer Res. (2005)
- Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. Morillas, M., Gómez-Puertas, P., Rubí, B., Clotet, J., Ariño, J., Valencia, A., Hegardt, F.G., Serra, D., Asins, G. J. Biol. Chem. (2002)
- Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A. López-Viñas, E., Bentebibel, A., Gurunathan, C., Morillas, M., de Arriaga, D., Serra, D., Asins, G., Hegardt, F.G., Gómez-Puertas, P. J. Biol. Chem. (2007)
- Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Pizer, E.S., Thupari, J., Han, W.F., Pinn, M.L., Chrest, F.J., Frehywot, G.L., Townsend, C.A., Kuhajda, F.P. Cancer Res. (2000)
- High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. Kudo, N., Barr, A.J., Barr, R.L., Desai, S., Lopaschuk, G.D. J. Biol. Chem. (1995)
- Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle. Vavvas, D., Apazidis, A., Saha, A.K., Gamble, J., Patel, A., Kemp, B.E., Witters, L.A., Ruderman, N.B. J. Biol. Chem. (1997)
- Purification and properties of a novel type of malonate decarboxylase from Acinetobacter calcoaceticus. Kim, Y.S., Byun, H.S. J. Biol. Chem. (1994)
- Molecular cloning, nucleotide sequence, and tissue distribution of malonyl-CoA decarboxylase. Jang, S.H., Cheesbrough, T.M., Kolattukudy, P.E. J. Biol. Chem. (1989)