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MeSH Review

Rheum

 
 
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Disease relevance of Rheum

 

High impact information on Rheum

 

Biological context of Rheum

 

Anatomical context of Rheum

 

Associations of Rheum with chemical compounds

  • Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor [9].
  • Locational variations in the quantity of five hydroxyanthraquinone derivatives (emodin glycoside (1), chrysophanol glycoside (2), emodin (3), chrysophanol (4) and physcion (5)) in the rhizomes of Rheum emodi are described [10].
  • Separation of hydroxyanthraquinone derivatives extracted from rheum with analytical high-speed counter-current chromatography [11].
  • Preparative isolation and purification of hydroxyanthraquinones and cinnamic acid from the chinese medicinal herb Rheum officinale Baill. by high-speed counter-current chromatography [12].
  • Preparative isolation and purification of trans-3,5,4'-trihydroxystilbene-4'-O-beta-D-glucopyranoside and (+)catechin from Rheum tanguticum Maxim. ex Balf. using high-speed counter-current chromatography by stepwise elution and stepwise increasing the flow-rate of the mobile phase [13].
 

Gene context of Rheum

  • Its efficacy as a disease-controlling agent in RA has been documented (Clin. Exp. Rheum. 11, p. 121, 1993) [14].
  • Synthesis of PGs in explant cultures was stimulated by a synthetic link peptide, identical in sequence to the N-terminus of the link protein (LP) of PG aggregates, in a similar manner to that demonstrated previously for human articular cartilage [Biochem. Soc. Trans. 25 (1997) 427; Arthritis Rheum. 41 (1998) 157] [15].
  • All scores were transformed into Sharp scores (Arthritis Rheum 1985;28:1449), including the important contributions of 3 Larsen scored publications [16].
  • Recently, McDaniel, et al (Arthritis Rheum 1987;30:894) reported a statistically significant association between ankylosing spondylitis (AS) and the presence in Pvu II digested genomic DNA of a 9.2 kb restriction fragment hybridizing with an HLA-B7 cDNA probe [17].
  • Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-alpha and IL-4 in RBL-2H3 cells [18].

References

  1. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. Zhang, J.H., Li, L.S., Zhang, M. Chin. Med. J. (1990) [Pubmed]
  2. Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation. Kwak, H.J., Park, M.J., Park, C.M., Moon, S.I., Yoo, D.H., Lee, H.C., Lee, S.H., Kim, M.S., Lee, H.W., Shin, W.S., Park, I.C., Rhee, C.H., Hong, S.I. Int. J. Cancer (2006) [Pubmed]
  3. Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. Yeh, F.T., Wu, C.H., Lee, H.Z. Int. J. Cancer (2003) [Pubmed]
  4. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan. Büttner, F.H., Hughes, C.E., Margerie, D., Lichte, A., Tschesche, H., Caterson, B., Bartnik, E. Biochem. J. (1998) [Pubmed]
  5. Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Chen, Y.C., Shen, S.C., Lee, W.R., Hsu, F.L., Lin, H.Y., Ko, C.H., Tseng, S.W. Biochem. Pharmacol. (2002) [Pubmed]
  6. High-performance thin layer chromatography method for quantitative determination of four major anthraquinone derivatives in Rheum emodi. Singh, N.P., Gupta, A.P., Sinha, A.K., Ahuja, P.S. Journal of chromatography. A. (2005) [Pubmed]
  7. Dietary rhubarb (Rheum rhaponticum) stalk fibre stimulates cholesterol 7 alpha-hydroxylase gene expression and bile acid excretion in cholesterol-fed C57BL/6J mice. Goel, V., Cheema, S.K., Agellon, L.B., Ooraikul, B., Basu, T.K. Br. J. Nutr. (1999) [Pubmed]
  8. Anti-platelet aggregation activity of stilbene derivatives from Rheum undulatum. Ko, S.K., Lee, S.M., Whang, W.K. Arch. Pharm. Res. (1999) [Pubmed]
  9. Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor. Yim, H., Lee, Y.H., Lee, C.H., Lee, S.K. Planta Med. (1999) [Pubmed]
  10. Determination and locational variations in the quantity of hydroxyanthraquinones and their glycosides in rhizomes of Rheum emodi using high-performance liquid chromatography. Verma, S.C., Singh, N.P., Sinha, A.K. Journal of chromatography. A. (2005) [Pubmed]
  11. Separation of hydroxyanthraquinone derivatives extracted from rheum with analytical high-speed counter-current chromatography. Zhang, T.Y., Pannell, L.K., Pu, Q.L., Cai, D.G., Ito, Y. J. Chromatogr. (1988) [Pubmed]
  12. Preparative isolation and purification of hydroxyanthraquinones and cinnamic acid from the chinese medicinal herb Rheum officinale Baill. by high-speed counter-current chromatography. Liu, R., Li, A., Sun, A. Journal of chromatography. A. (2004) [Pubmed]
  13. Preparative isolation and purification of trans-3,5,4'-trihydroxystilbene-4'-O-beta-D-glucopyranoside and (+)catechin from Rheum tanguticum Maxim. ex Balf. using high-speed counter-current chromatography by stepwise elution and stepwise increasing the flow-rate of the mobile phase. Jin, W., Tu, P.F. Journal of chromatography. A. (2005) [Pubmed]
  14. Oral desensitization in the treatment of human immune diseases. Vischer, T.L. Zeitschrift für Rheumatologie. (1995) [Pubmed]
  15. The effect of link peptide on proteoglycan synthesis in equine articular cartilage. Dean, M.F., Lee, Y.W., Dastjerdi, A.M., Lees, P. Biochim. Biophys. Acta (2003) [Pubmed]
  16. Radiographic evidence of disease progression in methotrexate treated and nonmethotrexate disease modifying antirheumatic drug treated rheumatoid arthritis patients: a meta-analysis. Alarcón, G.S., López-Méndez, A., Walter, J., Boerbooms, A.M., Russell, A.S., Furst, D.E., Rau, R., Drosos, A.A., Bartolucci, A.A. J. Rheumatol. (1992) [Pubmed]
  17. Association between ankylosing spondylitis and a 9.2 kb Pvu II class I HLA DNA restriction fragment: a reassessment. Durand, J.P., Taurog, J.D. J. Rheumatol. (1988) [Pubmed]
  18. Anti-allergic activity of stilbenes from Korean rhubarb (Rheum undulatum L.): structure requirements for inhibition of antigen-induced degranulation and their effects on the release of TNF-alpha and IL-4 in RBL-2H3 cells. Matsuda, H., Tewtrakul, S., Morikawa, T., Yoshikawa, M. Bioorg. Med. Chem. (2004) [Pubmed]
 
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