RecBC promoted repair of bleomycin damage in Escherichia coli.
The repair response of Escherichia coli K-12 to bleomycin was examined in Rec- mutants showing differential sensitivity to this agent. Sedimentation analysis of the cellular DNA showed incision after bleomycin treatment. The subsequent reformation of the DNA, found in the wild-type and the recD mutant, was abolished in the recB and delayed in the recF and recBC sbcB mutants. The bleomycin-induced SOS response was reduced in strains containing recB or recBC sbsB mutations. It is suggested that the RecBCD pathway has the main role in the efficient repair of bleomycin-induced DNA damage.[1]References
- RecBC promoted repair of bleomycin damage in Escherichia coli. Knezević-Vukcević, J., Simić, D. Biochimie (1991) [Pubmed]
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