Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors.
BACKGROUND: A flexible needle-catheter tissue-anchoring device was developed to accomplish full-thickness tissue apposition of the GI wall. The aim of this study was to identify the performance of this device for repair of large iatrogenic gastric perforations in a porcine model. OBJECTIVES: Six pigs. DESIGN: Short-term survival animal study. SETTINGS: Pigs were studied while they were under general anesthesia. Device performance in differing gastric locations and wall thicknesses was assessed by 2 perforations more than 2 cm in size created for each pig along the greater curvature and the anterior wall. INTERVENTIONS: Each perforation was closed by parallel placement of tissue anchor sets sequentially along the length of the perforation. MAIN OUTCOME MEASUREMENTS: One week follow-up endoscopy and necropsy were performed. RESULTS: Twelve perforations were closed with the 48 tissue anchor sets. All animals survived for 1 week without clinical complications. Follow-up endoscopy and necropsy revealed that all tissue anchors remained with firmly held sutures and sealed perforations. CONCLUSIONS: Full-thickness closure with a new tissue-anchoring device simply and successfully repaired large iatrogenic gastric perforations.[1]References
- Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors. Sumiyama, K., Gostout, C.J., Rajan, E., Bakken, T.A., Deters, J.L., Knipschield, M.A. Gastrointest. Endosc. (2007) [Pubmed]
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