Disease relevance of PIGS

• METHODS: Pigs were instrumented with a left anterior descending coronary artery (LAD) stenosis (1.5 mm) and underwent physiologic studies three to five months later to quantify regional function, perfusion and 18F-2-deoxyglucose (FDG) uptake [1].
• Isolation and Genetic Characterization of New Reassortant H3N1 Swine Influenza Virus from Pigs in the Midwestern United States [2].
• RESULTS: Pigs immunized with Ac-CT before ocular challenge with A. castellanii had significant anti-Acanthamoeba IgA antibody titers in their tears and enteric washes and were protected against ocular infection [3].
• INTERVENTIONS: Pigs were exposed to fecal peritonitis-induced septic shock [4].
• Presence of Pathogenicity Island Genes in Enterococcus faecalis Isolates from Pigs in Denmark [5].

High impact information on PIGS

• METHODS: Pigs were randomized to three groups: normal diet (N), high-cholesterol diet (HC) and HC diet plus simvastatin (HC+S) for 12 weeks [6].
• Subretinal Posterior Pole Injury Induces Selective Proliferation of RPE Cells in the Periphery in In Vivo Studies in Pigs [7].
• METHODS: Pigs were given 3 mg/kg/day of atorvastatin orally daily for 16 days, and then killed 24 hr after the last dose [8].
• METHODS: Pigs (n = 15) were chronically instrumented with a 1.5-mm stenosis of the left anterior descending coronary artery, a procedure that we have previously shown to produce viable chronically dysfunctional myocardium with reduced resting flow, or hibernating myocardium, after 3 mo [9].
• METHODS: Pigs were intraportally administered only saline in group 1 (n = 3), 1 microg/kg of lipopolysaccharide (LPS) in group 2 (n = 4), 0.1 mg/kg of alpha-amanitin in group 3 (n = 5), and amanitin plus LPS in group 4 (n = 9) [10].

Chemical compound and disease context of PIGS

• CONCLUSIONS: Pigs fed HP have hyperoxaluria and calcium oxalate crystalluria, and calcium oxalate papillary deposits form that may be precursors of kidney stones [11].
• METHODS AND RESULTS: Pigs instrumented with coronary snares and radiopaque markers within the area at risk were randomized to myocardial infarction-only (n = 10) or sMMPi (PGE-530742, 1 mg/kg TID) begun 3 days prior to myocardial infarction [12].
• (2) Pigs are the single animal species with receptors preferred by both avian (alpha 2-3 linked sialic acid to galactose) and human (alpha 2-6 linked sialic acid) influenza viruses, which supports their role as "mixing vessels" for reassortment between human and avian viruses [13].

Biological context of PIGS

• Ontogeny of Carnitine Palmitoyltransferase I Activity, Carnitine-Km, and mRNA Abundance in Pigs throughout Growth and Development [14].
• METHODS: Pigs (wt. 16-22 kg) underwent a simulated dive to 200 feet of seawater (fsw) (612.6 kPa) for 24 min, then decompressed at 60 fsw/min-1 (183 kPa.min-1) [15].
• BACKGROUND: Pigs have been widely used as animal models to study hemostasis [16].
• Animals with the more frequent haplotype present in Duroc and other commercial breeds exhibit higher ACP and CCP levels than the animals with haplotype specific to some Berlin Miniature Pigs [17].

Anatomical context of PIGS

• Feasibility of Endoscopic Ultrasound-Guided OncoGel (ReGel/Paclitaxel) Injection into the Pancreas in Pigs [18].
• Immunohistochemical MHC-II and Interleukin 2-R (CD25) Expression in Lymph Nodes of Pigs with Spontaneous Postweaning Multisystemic Wasting Syndrome (PMWS) [19].
• Influence of Short-term Confinement and Exercise on Tibia Development in Growing Pigs [20].
• HP was performed via the portal vein using ringerlactate solution of 4 degrees C. Pigs were assigned to three groups: TVE without HP (no-HP, n=9), TVE with HP at 28 degrees C (HP-28, n=6) and TVE with HP at 20 degrees C (HP-20, n=6) [21].
• Birth of Cloned Pigs from Zona-Free Nuclear Transfer Blastocysts Developed In Vitro before Transfer [22].

Associations of PIGS with chemical compounds

• RESULTS: Pigs anesthetized with desflurane using Baralyme exposed to 48 h of 10 l/min oxygen flow (reservoir bag removed) had extremely high carboxyhemoglobin concentrations (more than 80%) [23].
• A Continuous Dietary Supply of Free Calcium Formate Negatively Affects the Parietal Cell Population and Gastric RNA Expression for H+/K+-ATPase in Weaning Pigs [24].
• 1. Pigs were maintained in air or in an atmosphere of nitrous oxide which dramatically changes the S-adenosyl-L-methionine to S-adenosyl-L-homocysteine ratio in neural tissues [25].
• Diurnal Variation in Insulin-stimulated Systemic Glucose and Amino Acid Utilization in Pigs Fed with Identical Meals at 12-Hour Intervals [26].
• RESULTS: Pigs: In the pre-treatment experiments isoprenaline and procaterol showed similar effects [27].

Analytical, diagnostic and therapeutic context of PIGS

• Vaccination of Pigs against Swine Influenza Viruses by Using an NS1-Truncated Modified Live-Virus Vaccine [28].
• BACKGROUND: Pigs offer an unlimited source of xenografts for humans [29].
• METHODS: Pigs were placed on CPB for 3 hours using a membrane oxygenator with alpha-stat acid base management and arterial filtration [30].
• SETTINGS: Pigs were studied while they were under general anesthesia [31].
• 4. Pigs proved to be a good animal model for studies in paraquat poisoning and/or haemoperfusion [32].

References