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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Endoscopy


Psychiatry related information on Endoscopy

  • Six (13%) patients in the ciprofloxacin group and seven (16%) in the triple therapy group required urgent endoscopy or surgery for uncontrolled infection [6].
  • Retrograde amnesia effects of intravenous diazepam in endoscopy patients [7].
  • Compared with values obtained before sedation, the placebo group had significantly prolonged reaction times 30 min after completion of the endoscopy, whereas patients who received aminophylline did not [8].
  • RESULTS: Clinically speaking, the symptom score significantly improved over the period of 4 weeks, whereas other clinical parameters (computed tomography score, endoscopy score, rhinomanometric values, saccharine transport time, ciliary beat frequency, and olfaction) varied insignificantly [9].
  • The benzodiazepines, and in particular flunitrazepam, produced a significantly greater amnesia for the procedure, patients given these drugs being more willing to undergo repeat endoscopy [10].

High impact information on Endoscopy

  • RESULTS: At the time of endoscopy, active bleeding was evident in 28 of 91 patients in the vapreotide group (31 percent), as compared with 43 of 93 patients in the placebo group (46 percent) (P=0.03) [11].
  • Five patients (4.2 percent) in the omeprazole group and 12 (10 percent) in the placebo group died within 30 days after endoscopy (P=0.13) [12].
  • METHODS: We conducted a multicenter, double-blind comparison of gabexate (1 g given by intravenous infusion starting 30 to 90 minutes before endoscopy and continuing for 12 hours afterward) with placebo (mannitol and sodium chloride, administered in the same fashion) [13].
  • Video endoscopy of the larynx was performed and plasma histamine levels were obtained prior to and 30 minutes after cutaneous challenge of a patient with alkylphenol novolac resin [14].
  • Biochemical diagnosis is established by elevation of plasma chromogranin A (CgA), serotonin, or urinary 5-hydroxyindoleacetic acid (5-HIAA), while topographic localization is by Octreoscan, computerized axial tomography (CAT) scan, or endoscopy/ultrasound [15].

Chemical compound and disease context of Endoscopy


Biological context of Endoscopy


Anatomical context of Endoscopy


Associations of Endoscopy with chemical compounds


Gene context of Endoscopy

  • Given capsule endoscopy in celiac disease: evaluation of diagnostic accuracy and interobserver agreement [36].
  • Because serological discrimination between strain types would reduce the need for endoscopy, 61 patients carrying H. pylori were studied by vacA and cagA genotyping of H. pylori in gastric biopsy specimens and by detection of specific serum antibodies [37].
  • After matching controls (2:1 for cancers and 1:1 for adenomas) to cases by age, month of blood draw, fasting status, and indication for endoscopy (for adenoma controls), plasma IGF-1 and IGFBP-3 levels were measured [38].
  • METHODS: Duodenal biopsies from 25 patients with RA were obtained by endoscopy [39].
  • A randomized, double-blind, crossover comparative endoscopy study on the gastroduodenal tolerability of a highly specific cyclooxygenase-2 inhibitor, flosulide, and naproxen [40].

Analytical, diagnostic and therapeutic context of Endoscopy


  1. Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. Kelly, S.M., Pitcher, M.C., Farmery, S.M., Gibson, G.R. Gastroenterology (1994) [Pubmed]
  2. Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: a double-blind trial. Laine, L., Maller, E.S., Yu, C., Quan, H., Simon, T. Gastroenterology (2004) [Pubmed]
  3. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis.Rofecoxib Osteoarthritis Endoscopy Study Group. Laine, L., Harper, S., Simon, T., Bath, R., Johanson, J., Schwartz, H., Stern, S., Quan, H., Bolognese, J. Gastroenterology (1999) [Pubmed]
  4. Erythromycin intravenous bolus infusion in acute upper gastrointestinal bleeding: a randomized, controlled, double-blind trial. Frossard, J.L., Spahr, L., Queneau, P.E., Giostra, E., Burckhardt, B., Ory, G., De Saussure, P., Armenian, B., De Peyer, R., Hadengue, A. Gastroenterology (2002) [Pubmed]
  5. Is duodenitis a dyspeptic myth? Thomson, W.O., Joffe, S.N., Robertson, A.G., Lee, F.D., Imrie, C.W., Blumgart, L.H. Lancet (1977) [Pubmed]
  6. Intravenous ciprofloxacin as treatment for patients with acute suppurative cholangitis: a randomized, controlled clinical trial. Sung, J.J., Lyon, D.J., Suen, R., Chung, S.C., Co, A.L., Cheng, A.F., Leung, J.W., Li, A.K. J. Antimicrob. Chemother. (1995) [Pubmed]
  7. Retrograde amnesia effects of intravenous diazepam in endoscopy patients. Liu, S., Miller, N., Waye, J.D. Gastrointest. Endosc. (1984) [Pubmed]
  8. Low dose aminophylline accelerates recovery from diazepam premedication for digestive endoscopy. Foster, P.N., Moles, E.J., Sheard, C., Herbert, M., Atkinson, M. Gastrointest. Endosc. (1987) [Pubmed]
  9. Untreated chronic rhinosinusitis: a comparison of symptoms and mediator profiles. Kuehnemund, M., Ismail, C., Brieger, J., Schaefer, D., Mann, W.J. Laryngoscope (2004) [Pubmed]
  10. Premedication for upper gastrointestinal endoscopy: a comparative study of flunitrazepam, diazepam and neuroleptanalgesia. Nimmo, W.S., Forrest, J.A., Heading, R.C., Finlayson, N.D., Prescott, L.F. Endoscopy. (1978) [Pubmed]
  11. Early administration of vapreotide for variceal bleeding in patients with cirrhosis. Calès, P., Masliah, C., Bernard, B., Garnier, P.P., Silvain, C., Szostak-Talbodec, N., Bronowicki, J.P., Ribard, D., Botta-Fridlund, D., Hillon, P., Besseghir, K., Lebrec, D. N. Engl. J. Med. (2001) [Pubmed]
  12. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. Lau, J.Y., Sung, J.J., Lee, K.K., Yung, M.Y., Wong, S.K., Wu, J.C., Chan, F.K., Ng, E.K., You, J.H., Lee, C.W., Chan, A.C., Chung, S.C. N. Engl. J. Med. (2000) [Pubmed]
  13. Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy--Italian Group. Cavallini, G., Tittobello, A., Frulloni, L., Masci, E., Mariana, A., Di Francesco, V. N. Engl. J. Med. (1996) [Pubmed]
  14. Acute systemic reactions to carbonless copy paper associated with histamine release. LaMarte, F.P., Merchant, J.A., Casale, T.B. JAMA (1988) [Pubmed]
  15. Current status of gastrointestinal carcinoids. Modlin, I.M., Kidd, M., Latich, I., Zikusoka, M.N., Shapiro, M.D. Gastroenterology (2005) [Pubmed]
  16. Methemoglobinemia as a complication of 20% benzocaine spray for endoscopy. Collins, J.F. Gastroenterology (1990) [Pubmed]
  17. A multicenter, randomized, clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia. Junquera, F., Feu, F., Papo, M., Videla, S., Armengol, J.R., Bordas, J.M., Saperas, E., Piqué, J.M., Malagelada, J.R. Gastroenterology (2001) [Pubmed]
  18. Systemic antibiotic therapy prevents bacterial infection in cirrhotic patients with gastrointestinal hemorrhage. Blaise, M., Pateron, D., Trinchet, J.C., Levacher, S., Beaugrand, M., Pourriat, J.L. Hepatology (1994) [Pubmed]
  19. Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. Simon, L.S., Lanza, F.L., Lipsky, P.E., Hubbard, R.C., Talwalker, S., Schwartz, B.D., Isakson, P.C., Geis, G.S. Arthritis Rheum. (1998) [Pubmed]
  20. Gastric form of alpha chain disease. Coulbois, J., Galian, P., Galian, A., Couteaux, B., Danon, F., Rambaud, J. Gut (1986) [Pubmed]
  21. Diagnosis of Helicobacter pylori infection with a new non-invasive antigen-based assay. HpSA European study group. Vaira, D., Malfertheiner, P., Mégraud, F., Axon, A.T., Deltenre, M., Hirschl, A.M., Gasbarrini, G., O'Morain, C., Garcia, J.M., Quina, M., Tytgat, G.N. Lancet (1999) [Pubmed]
  22. Aldehyde disinfectants and health in endoscopy units. British Society of Gastroenterology Endoscopy Committee. Cowan, R.E., Manning, A.P., Ayliffe, G.A., Axon, A.T., Causton, J.S., Cripps, N.F., Hall, R., Hanson, P.J., Harrison, J., Leicester, R.J. Gut (1993) [Pubmed]
  23. New disinfecting apparatus for gastrointestinal fibre-endoscopes. O'Connor, H.J., Rothwell, J., Maxwell, S., Lincoln, C., Axon, A.T. Gut (1982) [Pubmed]
  24. Risk factors for oesophageal squamous dysplasia in adult inhabitants of a high risk region of China. Wei, W.Q., Abnet, C.C., Lu, N., Roth, M.J., Wang, G.Q., Dye, B.A., Dong, Z.W., Taylor, P.R., Albert, P., Qiao, Y.L., Dawsey, S.M. Gut (2005) [Pubmed]
  25. A predictive model for failure to control bleeding during acute variceal haemorrhage. Ben-Ari, Z., Cardin, F., McCormick, A.P., Wannamethee, G., Burroughs, A.K. J. Hepatol. (1999) [Pubmed]
  26. Omeprazole 20 mg three days a week and 10 mg daily in prevention of duodenal ulcer relapse. Double-blind comparative trial. Lauritsen, K., Andersen, B.N., Laursen, L.S., Hansen, J., Havelund, T., Eriksen, J., Rehfeld, J.F., Kjaergaard, J., Rask-Madsen, J. Gastroenterology (1991) [Pubmed]
  27. Vitamin C in the human stomach: relation to gastric pH, gastroduodenal disease, and possible sources. O'Connor, H.J., Schorah, C.J., Habibzedah, N., Axon, A.T., Cockel, R. Gut (1989) [Pubmed]
  28. Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner. Bebb, J.R., Letley, D.P., Thomas, R.J., Aviles, F., Collins, H.M., Watson, S.A., Hand, N.M., Zaitoun, A., Atherton, J.C. Gut (2003) [Pubmed]
  29. Increased beta-catenin mRNA levels and mutational alterations of the APC and beta-catenin gene are present in intestinal-type gastric cancer. Ebert, M.P., Fei, G., Kahmann, S., Müller, O., Yu, J., Sung, J.J., Malfertheiner, P. Carcinogenesis (2002) [Pubmed]
  30. Treatment of AIDS-associated gastrointestinal cytomegalovirus infection with foscarnet and ganciclovir: a randomized comparison. Blanshard, C., Benhamou, Y., Dohin, E., Lernestedt, J.O., Gazzard, B.G., Katlama, C. J. Infect. Dis. (1995) [Pubmed]
  31. Propofol for endoscopy sedation. Bassett, M., Ashton, C., Gavaghan, T., Hillman, L., Kaye, G., Clarke, A. Gastroenterology (2003) [Pubmed]
  32. Treatment of duodenal ulcer with cimetidine. Haggie, S.J., Fermont, D.C., Wyllie, J.H. Lancet (1976) [Pubmed]
  33. Patients appreciate premedication for endoscopy. Thompson, D.G., Lennard-Jones, J.E., Evans, S.J., Cowan, R.E., Murray, R.S., Wright, J.T. Lancet (1980) [Pubmed]
  34. Glutaraldehyde allergy in endoscopy units. Calder, I.M., Wright, L.P., Grimstone, D. Lancet (1992) [Pubmed]
  35. Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. Helicobacter Eradication for Lesion Prevention. Hawkey, C.J., Tulassay, Z., Szczepanski, L., van Rensburg, C.J., Filipowicz-Sosnowska, A., Lanas, A., Wason, C.M., Peacock, R.A., Gillon, K.R. Lancet (1998) [Pubmed]
  36. Given capsule endoscopy in celiac disease: evaluation of diagnostic accuracy and interobserver agreement. Petroniene, R., Dubcenco, E., Baker, J.P., Ottaway, C.A., Tang, S.J., Zanati, S.A., Streutker, C.J., Gardiner, G.W., Warren, R.E., Jeejeebhoy, K.N. Am. J. Gastroenterol. (2005) [Pubmed]
  37. Assessment of Helicobacter pylori vacA and cagA genotypes and host serological response. Figueiredo, C., Quint, W., Nouhan, N., van den Munckhof, H., Herbrink, P., Scherpenisse, J., de Boer, W., Schneeberger, P., Perez-Perez, G., Blaser, M.J., van Doorn, L.J. J. Clin. Microbiol. (2001) [Pubmed]
  38. A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. Giovannucci, E., Pollak, M.N., Platz, E.A., Willett, W.C., Stampfer, M.J., Majeed, N., Colditz, G.A., Speizer, F.E., Hankinson, S.E. Cancer Epidemiol. Biomarkers Prev. (2000) [Pubmed]
  39. Increased HLA-DR and CD44 antigen expression in the gut: evidence of extraarticular immunological activity in rheumatoid arthritis. Abuzakouk, M., Feighery, C., Kelleher, D., O'Briain, D.S., Jones, E., Weir, D., Casey, E., O'Farrelly, C. J. Rheumatol. (1999) [Pubmed]
  40. A randomized, double-blind, crossover comparative endoscopy study on the gastroduodenal tolerability of a highly specific cyclooxygenase-2 inhibitor, flosulide, and naproxen. Bjarnason, I., Macpherson, A., Rotman, H., Schupp, J., Hayllar, J. Scand. J. Gastroenterol. (1997) [Pubmed]
  41. Topical lidocaine in preendoscopic medication. Gordon, M.J., Mayes, G.R., Meyer, G.W. Gastroenterology (1976) [Pubmed]
  42. Endoscopic monitoring of Crohn's disease treatment: a prospective, randomized clinical trial. The Groupe d'Etudes Therapeutiques des Affections Inflammatoires Digestives. Landi, B., Anh, T.N., Cortot, A., Soule, J.C., Rene, E., Gendre, J.P., Bories, P., See, A., Metman, E.H., Florent, C. Gastroenterology (1992) [Pubmed]
  43. Diagnostic inconsistencies in Barrett's esophagus. Department of Veterans Affairs Gastroesophageal Reflux Study Group. Kim, S.L., Waring, J.P., Spechler, S.J., Sampliner, R.E., Doos, W.G., Krol, W.F., Williford, W.O. Gastroenterology (1994) [Pubmed]
  44. Endoscopic variceal sclerosis does not increase the risk of portal venous thrombosis. Kawasaki, S., Henderson, J.M., Riepe, S.P., Brooks, W.S., Hertzler, G. Gastroenterology (1992) [Pubmed]
  45. Carbon dioxide retention and oxygen desaturation during gastrointestinal endoscopy. Freeman, M.L., Hennessy, J.T., Cass, O.W., Pheley, A.M. Gastroenterology (1993) [Pubmed]
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