Hosting neurotoxicity in polyglutamine disease.
Polyglutamine diseases are caused by an expanded glutamine domain thought to confer a toxic activity onto the respective disease proteins. In this issue, propose that toxicity of the polyglutamine protein Ataxin-1 may not be due to abberant protein interactions mediated by the polyglutamine expansion. Instead, they suggest that toxicity is solely due to interactions of Ataxin-1 with its normal binding partners.[1]References
- Hosting neurotoxicity in polyglutamine disease. Liu, N., Bonini, N.M. Cell (2006) [Pubmed]
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