The Norcoclaurine Pathway is Operative in Berberine Biosynthesis in Coptis japonica.
The commercially used cell suspension culture of COPTIS JAPONICA Makino (Ranunculaceae) incorporates [beta- (13)C]tyrosine into both halves of the berberine molecule (isoquinoline and benzyl portion) while L-[3'- (18)O]DOPA only labels the isoquinoline portion of this molecule. This labelling pattern indicates that different C (6)-C (2) units derived from tyrosine form this molecule. This result and the incorporation of ( S)-[1- (13)C] norcoclaurine into berberine demonstrates that the biosynthesis of protoberberine alkaloids in COPTIS involves the norcoclaurine but not the norlaudanosoline pathway.[1]References
- The Norcoclaurine Pathway is Operative in Berberine Biosynthesis in Coptis japonica. Müller, M.J., Zenk, M.H. Planta Med. (1992) [Pubmed]
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