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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Ranunculaceae


High impact information on Ranunculaceae


Chemical compound and disease context of Ranunculaceae


Biological context of Ranunculaceae


Anatomical context of Ranunculaceae


Associations of Ranunculaceae with chemical compounds


Gene context of Ranunculaceae

  • Cloning of peroxiredoxin, a novel antioxidant enzyme, from the helminth parasite Fasciola hepatica [30].
  • Since a human IL-4delta2 was assumed to act as competitive inhibitor of IL-4, it was important to know whether expression of these splice variants of bovine IL-4 have a regulatory function during an immune response to infection with F. hepatica [31].
  • Interestingly, PBMCs responded to stimulation with F. hepatica secretory-excretory products (FhSEP) already on PID 10 and expressed high amounts of IL-4 but not of IFN-gamma mRNA suggesting that F. hepatica induced a Th2 biased early immune response which was not restricted to the site of infection [31].
  • Inhibition of COXs and 5-LOX and activation of PPARs by Australian Clematis species (Ranunculaceae) [32].
  • Mice with a coinfection of F. hepatica and B. pertussis exhibited a Th2 cytokine profile in response to F. hepatica antigens, similar to those infected with F. hepatica alone [2].

Analytical, diagnostic and therapeutic context of Ranunculaceae


  1. Molecular cloning and expression of Cu/Zn-containing superoxide dismutase from Fasciola hepatica. Kim, T.S., Jung, Y., Na, B.K., Kim, K.S., Chung, P.R. Infect. Immun. (2000) [Pubmed]
  2. Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis. Brady, M.T., O'Neill, S.M., Dalton, J.P., Mills, K.H. Infect. Immun. (1999) [Pubmed]
  3. Immunity in Schistosoma mansoni using antigens of Fasciola hepatica isolated by concanavalin A affinity chromatography. Hillyer, G.V., Sagramoso de Ateca, L. Infect. Immun. (1979) [Pubmed]
  4. Identification of a 17-kilodalton Fasciola hepatica immunodiagnostic antigen by the enzyme-linked immunoelectrotransfer blot technique. Hillyer, G.V., Soler de Galanes, M. J. Clin. Microbiol. (1988) [Pubmed]
  5. Vaccination of sheep against Fasciola hepatica with glutathione S-transferase. Identification and mapping of antibody epitopes on a three-dimensional model of the antigen. Sexton, J.L., Wilce, M.C., Colin, T., Wijffels, G.L., Salvatore, L., Feil, S., Parker, M.W., Spithill, T.W., Morrison, C.A. J. Immunol. (1994) [Pubmed]
  6. Production and properties of a mouse monoclonal IgE antibody to Schistosoma japonicum. Kojima, S., Niimura, M., Kanazawa, T. J. Immunol. (1987) [Pubmed]
  7. 5-Hydroxytryptamine and motility in Fasciola hepatica. Holden-Dye, L., Walker, R.J. Parasitol. Today (Regul. Ed.) (1993) [Pubmed]
  8. A study in scarlet: enzymes of ketocarotenoid biosynthesis in the flowers of Adonis aestivalis. Cunningham, F.X., Gantt, E. Plant J. (2005) [Pubmed]
  9. Fascioliasis in developed countries: a review of classic and aberrant forms of the disease. Arjona, R., Riancho, J.A., Aguado, J.M., Salesa, R., González-Macías, J. Medicine (Baltimore) (1995) [Pubmed]
  10. Immunodiagnosis of fasciolosis using recombinant procathepsin L cystein proteinase. Carnevale, S., Rodríguez, M.I., Guarnera, E.A., Carmona, C., Tanos, T., Angel, S.O. Diagn. Microbiol. Infect. Dis. (2001) [Pubmed]
  11. Anthelmintic efficacy of albendazole in calves with naturally acquired Fasciola hepatica infections. Bradley, R.E., Randell, W.F., Armstrong, D.A. Am. J. Vet. Res. (1981) [Pubmed]
  12. Chemoprophylaxis with diamfenetide against experimental infections of Fasciola hepatica in ruminants. Enzie, F.D., Rew, R.S., Colglazier, M.L. Am. J. Vet. Res. (1980) [Pubmed]
  13. Trematodiasis in Turkey: comparative efficacy of triclabendazole and niclofolan against natural infections of Fasciola hepatica and F. gigantica in sheep. Güralp, N., Tinar, R. J. Helminthol. (1984) [Pubmed]
  14. The anthelmintic efficacy of mebendazole against adult Fasciola hepatica and a concurrent mixed nematode infection in sheep. Kelly, J.D., Chevis, R.A., Whitlock, H.V. New Zealand veterinary journal. (1975) [Pubmed]
  15. Beneficial effect of dexamethasone on attenuated hormone-induced uptake of calcium and glycogenolysis by perfused liver of rats infected with Fasciola hepatica. Hanisch, M.J., Behm, C.A., Bygrave, F.L. FEBS Lett. (1991) [Pubmed]
  16. The metabolic profile of adult Fasciola hepatica obtained from rafoxanide-treated sheep. Prichard, R.K. Parasitology (1978) [Pubmed]
  17. Fasciola hepatica cysteine proteinases: immunodominant antigens in human fascioliasis. Cordova, M., Herrera, P., Nopo, L., Bellatin, J., Naquira, C., Guerra, H., Espinoza, J.R. Am. J. Trop. Med. Hyg. (1997) [Pubmed]
  18. In vivo regulation of phosphorylation level and activity of phosphofructokinase by serotonin in Fasciola hepatica. Kamemoto, E.S., Lan, L., Mansour, T.E. Arch. Biochem. Biophys. (1989) [Pubmed]
  19. Rhodoquinone is synthesized de novo by Fasciola hepatica. Van Hellemond, J.J., Luijten, M., Flesch, F.M., Gaasenbeek, C.P., Tielens, A.G. Mol. Biochem. Parasitol. (1996) [Pubmed]
  20. Interleukin-10 is expressed by bovine type 1 helper, type 2 helper, and unrestricted parasite-specific T-cell clones and inhibits proliferation of all three subsets in an accessory-cell-dependent manner. Brown, W.C., Woods, V.M., Chitko-McKown, C.G., Hash, S.M., Rice-Ficht, A.C. Infect. Immun. (1994) [Pubmed]
  21. Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages. Donnelly, S., O'Neill, S.M., Sekiya, M., Mulcahy, G., Dalton, J.P. Infect. Immun. (2005) [Pubmed]
  22. Photoreactivity of lysergic acid diethylamide and its possible utility as a photoaffinity labeling reagent. Walker, E.B., McNall, S.J., Mansour, T.E. Biochem. Pharmacol. (1983) [Pubmed]
  23. Fasciola hepatica: the effect of the microtubule inhibitors colchicine and tubulozole-C on the ultrastructure of the adult fluke. Stitt, A.W., Fairweather, I. Parasitology (1993) [Pubmed]
  24. Protection of Fasciola hepatica in the gut mucosa of immune rats is associated with infiltrates of eosinophils, IgG1 and IgG2a antibodies around the parasites. Van Milligen, F.J., Cornelissen, J.B., Hendriks, I.M., Gaasenbeek, C.P., Bokhout, B.A. Parasite Immunol. (1998) [Pubmed]
  25. Glutathione S-transferase. Novel vaccine against Fasciola hepatica infection in sheep. Sexton, J.L., Milner, A.R., Panaccio, M., Waddington, J., Wijffels, G., Chandler, D., Thompson, C., Wilson, L., Spithill, T.W., Mitchell, G.F. J. Immunol. (1990) [Pubmed]
  26. Adenylate cyclase from Fasciola hepatica. 1. Ligand specificity of adenylate cyclase-coupled serotonin receptors. Northup, J.K., Mansour, T.E. Mol. Pharmacol. (1978) [Pubmed]
  27. Adenylate cyclase from Fasciola hepatica. 2. Role of guanine nucleotides in coupling adenylate cyclase and serotonin receptors. Northup, J.K., Mansour, T.E. Mol. Pharmacol. (1978) [Pubmed]
  28. Platyhelminth mitochondrial DNA: evidence for early evolutionary origin of a tRNA(serAGN) that contains a dihydrouridine arm replacement loop, and of serine-specifying AGA and AGG codons. Garey, J.R., Wolstenholme, D.R. J. Mol. Evol. (1989) [Pubmed]
  29. Effect of some phosphodiesterase inhibitors on adenylate cyclase from the liver fluke, Fasciola hepatica. Mansour, T.E., Mansour, J.M. Biochem. Pharmacol. (1979) [Pubmed]
  30. Cloning of peroxiredoxin, a novel antioxidant enzyme, from the helminth parasite Fasciola hepatica. McGonigle, S., Curley, G.P., Dalton, J.P. Parasitology (1997) [Pubmed]
  31. Expression of interleukin 4, interleukin 4 splice variants and interferon gamma mRNA in calves experimentally infected with Fasciola hepatica. Waldvogel, A.S., Lepage, M.F., Zakher, A., Reichel, M.P., Eicher, R., Heussler, V.T. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  32. Inhibition of COXs and 5-LOX and activation of PPARs by Australian Clematis species (Ranunculaceae). Li, R.W., Lin, G.D., Leach, D.N., Waterman, P.G., Myers, S.P. Journal of ethnopharmacology. (2006) [Pubmed]
  33. Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease. Cornelissen, J.B., Gaasenbeek, C.P., Borgsteede, F.H., Holland, W.G., Harmsen, M.M., Boersma, W.J. Int. J. Parasitol. (2001) [Pubmed]
  34. The synthesis and utilization of 2,4-dinitrophenyl-labeled irreversible peptidyl diazomethyl ketone inhibitors. Hawthorne, S.J., Pagano, M., Harriott, P., Halton, D.W., Walker, B. Anal. Biochem. (1998) [Pubmed]
  35. Sequence analysis of a Fasciola hepatica glutathione S-transferase cDNA clone. Muro, A., Rodriguez-Medina, J.R., Hillyer, G.V. Am. J. Trop. Med. Hyg. (1993) [Pubmed]
  36. Immunohistochemical and electrochemical detection of serotonin in the nervous system of Fasciola hepatica, a parasitic flatworm. Sukhdeo, S.C., Sukhdeo, M.V. Brain Res. (1988) [Pubmed]
  37. Preparation and in vitro translation of mRNA from Fasciola hepatica. Irving, D.O., Howell, M.J. Mol. Biochem. Parasitol. (1981) [Pubmed]
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