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Chemical Compound Review

Higenamine     1-[(4-hydroxyphenyl)methyl]- 1,2,3,4...

Synonyms: Norcoclaurine, CHEMBL19344, SureCN636788, CHEBI:18418, LS-54621, ...
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Disease relevance of Norcoclaurine


High impact information on Norcoclaurine


Biological context of Norcoclaurine


Anatomical context of Norcoclaurine


Associations of Norcoclaurine with other chemical compounds


Gene context of Norcoclaurine


Analytical, diagnostic and therapeutic context of Norcoclaurine


  1. Inhibition of activation of nuclear factor kappaB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root. Kang, Y.J., Lee, Y.S., Lee, G.W., Lee, D.H., Ryu, J.C., Yun-Choi, H.S., Chang, K.C. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  2. Measurement of effects of the Chinese herbal medicine higenamine on left ventricular function using a cardiac probe. Liu, X.J., Wagner, H.N., Tao, S. European journal of nuclear medicine. (1983) [Pubmed]
  3. Anti-thrombotic effects of higenamine. Yun-Choi, H.S., Pyo, M.K., Park, K.M., Chang, K.C., Lee, D.H. Planta Med. (2001) [Pubmed]
  4. Acute toxicity of higenamine in mice. Lo, C.F., Chen, C.M. Planta Med. (1997) [Pubmed]
  5. The effects of higenamine on LPS-induced experimental disseminated intravascular coagulation (DIC) in rats. Yun-Choi, H.S., Pyo, M.K., Chang, K.C., Lee, D.H. Planta Med. (2002) [Pubmed]
  6. Inhibitory effects of higenamine on dopamine content in PC12 cells. Shin, J.S., Yun-Choi, H.S., Kim, E.I., Lee, M.K. Planta Med. (1999) [Pubmed]
  7. Effects of higenamine on regulation of ion transport in guinea pig distal colon. Liu, W., Sato, Y., Hosoda, Y., Hirasawa, K., Hanai, H. Jpn. J. Pharmacol. (2000) [Pubmed]
  8. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Chang, K.C., Chong, W.S., Lee, I.J. Can. J. Physiol. Pharmacol. (1994) [Pubmed]
  9. Effect of higenamine on action potential of ventricular myocardial cells. Yu, G.R., Wang, B.Y., Zheng, D.S., Huang, M.X., Gu, B.K., Chen, Y.L., Shang, M., Jin, Z.J., Cheng, T.O. Journal of electrocardiology. (1985) [Pubmed]
  10. Pharmacokinetics of higenamine in rabbits. Lo, C.F., Chen, C.M. Biopharmaceutics & drug disposition. (1996) [Pubmed]
  11. Endothelium-dependent higenamine-induced aortic relaxation in isolated rat aorta. Wong, K.K., Lo, C.F., Chen, C.M. Planta Med. (1997) [Pubmed]
  12. Inhibition of lipopolysaccharide-induced inducible nitric oxide (iNOS) mRNA expression and nitric oxide production by higenamine in murine peritoneal macrophages. Lee, H.Y., Lee, J.S., Kim, E.J., Han, J.W., Lee, H.W., Kang, Y.J., Chang, K.C. Arch. Pharm. Res. (1999) [Pubmed]
  13. Effect of acute higenamine administration on bradyarrhythmias and HIS bundle. A clinical study of 14 cases and animal experiment on dogs. Bao, Y.X., Yu, G.R., Xu, J.M., Xu, Y.Q., Bian, Y.T., Zheng, D.S. Chin. Med. J. (1982) [Pubmed]
  14. Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells. Sato, F., Tsujita, T., Katagiri, Y., Yoshida, S., Yamada, Y. Eur. J. Biochem. (1994) [Pubmed]
  15. The Norcoclaurine Pathway is Operative in Berberine Biosynthesis in Coptis japonica. Müller, M.J., Zenk, M.H. Planta Med. (1992) [Pubmed]
  16. Counter effects of higenamine and coryneine, components of aconite root, on acetylcholine release from motor nerve terminal in mice. Nojima, H., Okazaki, M., Kimura, I. Journal of Asian natural products research. (2000) [Pubmed]
  17. Higenamine reduces apoptotic cell death by induction of heme oxygenase-1 in rat myocardial ischemia-reperfusion injury. Lee, Y.S., Kang, Y.J., Kim, H.J., Park, M.K., Seo, H.G., Lee, J.H., Yun-Choi, H.S., Chang, K.C. Apoptosis (2006) [Pubmed]
  18. Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria. Kimura, I., Makino, M., Takamura, Y., Islam, M.A., Kimura, M. Jpn. J. Pharmacol. (1994) [Pubmed]
  19. Enantiomers of higenamine inhibit LPS-induced iNOS in a macrophage cell line and improve the survival of mice with experimental endotoxemia. Park, J.E., Kang, Y.J., Park, M.K., Lee, Y.S., Kim, H.J., Seo, H.G., Lee, J.H., Hye Sook, Y.C., Shin, J.S., Lee, H.W., Ahn, S.K., Chang, K.C. Int. Immunopharmacol. (2006) [Pubmed]
  20. Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis. Samanani, N., Liscombe, D.K., Facchini, P.J. Plant J. (2004) [Pubmed]
  21. Determination of higenamine in plasma and urine by high-performance liquid chromatography with electrochemical detection. Lo, C.F., Chen, C.M. J. Chromatogr. B, Biomed. Appl. (1994) [Pubmed]
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