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MeSH Review

Coptis

 
 
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Disease relevance of Coptis

  • The antibacterial pharmacodynamics against E. coli of Chinese medicine (CM) Rhizoma coptidis (Coptis Root) and its formula Sanhuang, and the control antibiotics enoxacin, were analyzed by a concentration-killing curve (CKC) approach, and the novel parameters BC50 and r for antibacterial potency were proposed [1].
 

High impact information on Coptis

  • Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica [2].
  • cDNA clones for the (S)-tetrahydroberberine (H4Ber) oxidase of cultured berberine-producing Coptis japonica cells were isolated by screening a C. japonica cDNA library with synthetic nucleotides that can encode the NH2-terminal sequence of this enzyme [3].
  • Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells [4].
  • Two cytochrome P450 (P450) cDNAs involved in the biosynthesis of berberine, an antimicrobial benzylisoquinoline alkaloid, were isolated from cultured Coptis japonica cells and characterized [4].
  • Molecular cloning and characterization of coclaurine N-methyltransferase from cultured cells of Coptis japonica [5].
 

Biological context of Coptis

 

Anatomical context of Coptis

 

Associations of Coptis with chemical compounds

  • Molecular characterization of the S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica [9].
  • Three protoberberine alkaloids jatrorrhizine, berberine and palmatine were isolated from the monoamine oxidase (MAO) inhibitory fraction of the methanol extract of Coptis chinensis rhizoma [10].
  • Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells [11].
  • Baicalein, berberine, curcumin and hesperidin are the major components derived from Scutellaria baicalensis, Coptis japonica, Curcuma longa and Poncirus trifoliata, respectively [12].
  • The vanadate-induced nucleotide trapping technique, which has been conventionally used to characterize mammalian ATP-binding cassette (ABC) proteins, was applied to berberine-producing plant cell cultures, Thalictrum minus and Coptis japonica [13].
 

Gene context of Coptis

 

Analytical, diagnostic and therapeutic context of Coptis

  • The anti-feeding activity of 3 isoquinoline alkaloids identified from roots of Coptis japonica Makino toward 4th-instar larvae of Hyphantria cunea Drury and adults of Agelastica coerulea Baly was examined using the leaf-dipping bioassay [18].

References

  1. A novel approach to estimate in vitro antibacterial potency of Chinese medicine using a concentration-killing curve method. Liu, Y.Q., Zhang, Y.Z., Sun, C.Y., Gao, P.J. Am. J. Chin. Med. (2005) [Pubmed]
  2. Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica. Shitan, N., Bazin, I., Dan, K., Obata, K., Kigawa, K., Ueda, K., Sato, F., Forestier, C., Yazaki, K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Isolation, sequence, and bacterial expression of a cDNA for (S)-tetrahydroberberine oxidase from cultured berberine-producing Coptis japonica cells. Okada, N., Koizumi, N., Tanaka, T., Ohkubo, H., Nakanishi, S., Yamada, Y. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. Molecular cloning and characterization of CYP719, a methylenedioxy bridge-forming enzyme that belongs to a novel P450 family, from cultured Coptis japonica cells. Ikezawa, N., Tanaka, M., Nagayoshi, M., Shinkyo, R., Sakaki, T., Inouye, K., Sato, F. J. Biol. Chem. (2003) [Pubmed]
  5. Molecular cloning and characterization of coclaurine N-methyltransferase from cultured cells of Coptis japonica. Choi, K.B., Morishige, T., Shitan, N., Yazaki, K., Sato, F. J. Biol. Chem. (2002) [Pubmed]
  6. Anti-acne effects of Oriental herb extracts: a novel screening method to select anti-acne agents. Nam, C., Kim, S., Sim, Y., Chang, I. Skin Pharmacol. Appl. Skin Physiol. (2003) [Pubmed]
  7. Inhibitory effects of protoberberine alkaloids from the roots of Coptis japonica on catecholamine biosynthesis in PC12 cells. Lee, M.K., Kim, H.S. Planta Med. (1996) [Pubmed]
  8. Transient RNA silencing of scoulerine 9-O-methyltransferase expression by double stranded RNA in Coptis japonica protoplasts. Dubouzet, J.G., Morishige, T., Fujii, N., An, C.I., Fukusaki, E., Ifuku, K., Sato, F. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
  9. Molecular characterization of the S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica. Morishige, T., Tsujita, T., Yamada, Y., Sato, F. J. Biol. Chem. (2000) [Pubmed]
  10. Monoamine oxidase inhibitors from rhizoma of Coptis chinensis. Kong, L.D., Cheng, C.H., Tan, R.X. Planta Med. (2001) [Pubmed]
  11. Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells. Sato, F., Tsujita, T., Katagiri, Y., Yoshida, S., Yamada, Y. Eur. J. Biochem. (1994) [Pubmed]
  12. Effects of baicalein, berberine, curcumin and hesperidin on mucin release from airway goblet cells. Lee, C.J., Lee, J.H., Seok, J.H., Hur, G.M., Park, Y.C., Seol, I.C., Kim, Y.H. Planta Med. (2003) [Pubmed]
  13. Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins. Terasaka, K., Shitan, N., Sato, F., Maniwa, F., Ueda, K., Yazaki, K. Plant Cell Physiol. (2003) [Pubmed]
  14. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Kobayashi, Y., Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. Planta Med. (1995) [Pubmed]
  15. Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids. Lee, H.S. J. Agric. Food Chem. (2002) [Pubmed]
  16. Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in. Tanabe, H., Suzuki, H., Nagatsu, A., Mizukami, H., Ogihara, Y., Inoue, M. Phytomedicine (2006) [Pubmed]
  17. Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on tumor necrosis factor-alpha production in lipopolysaccharide-stimulated RAW264.7 cells. Cho, J.Y., Park, J., Yoo, E.S., Yoshikawa, K., Baik, K.U., Lee, J., Park, M.H. Arch. Pharm. Res. (1998) [Pubmed]
  18. Antifeeding activity of isoquinoline alkaloids identified in Coptis japonica roots against Hyphantria cunea (Lepidoptera: Arctiidae) and Agelastica coerulea (Coleoptera: Galerucinae). Park, I.K., Lee, H.S., Lee, S.G., Park, J.D., Ahn, Y.J. J. Econ. Entomol. (2000) [Pubmed]
 
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