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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy.

The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly expressed in many other epithelial carcinomas. Recent studies suggest its significant potential as a clinical tool for cancer diagnosis and prognosis. MUC4 modulates HER2/ErbB2 signaling and is a determinant of therapeutic outcome of Herceptin-based therapy, which further indicates its prospective usefulness in cancer therapy and treatment planning.[1]

References

  1. Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy. Singh, A.P., Chaturvedi, P., Batra, S.K. Cancer Res. (2007) [Pubmed]
 
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