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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Bioassay-guided isolation of antifungal alkaloids from Melochia odorata.

An alkaloidal extract of the leaves of Melochia odorata exhibited antifungal activity against Candida albicans, Cryptococcus neoformans and Saccharomyces cerevisiae using a TLC bioautographic method. Bioassay-guided fractionation of this extract using separation by normal and reverse high-performance liquid chromatography (HPLC) resulted in the isolation of two active compounds identified as frangulanine, a cyclic peptide alkaloid, and waltherione-A, a quinolinone alkaloid. Copyright (c) 2007 John Wiley & Sons, Ltd.[1]


  1. Bioassay-guided isolation of antifungal alkaloids from Melochia odorata. Emile, A., Waikedre, J., Herrenknecht, C., Fourneau, C., Gantier, J.C., Hnawia, E., Cabalion, P., Hocquemiller, R., Fournet, A. Phytotherapy research : PTR (2007) [Pubmed]
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