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Chemical Compound Review

AC1NSUSW     2-dimethylamino-3-methyl-N- [(10Z)-7-(2...

Synonyms: AC1NSVIN
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High impact information on Frangulanine

  • Frangufoline, a sedative 14-membered frangulanine-type cyclopeptide alkaloid, was found to be rapidly converted, via enzymatic process, in vitro and in vivo in rodents to M1 ((S)-(N,N-dimethylphenylalanyl)-(2S,3S)-3-[(p-formylphenoxy) leucyl]-(S)-leucine); which is a substituted linear tripeptide [1].
  • Frangulanine induced mitochondrial swelling in 0.15 M KCl solution at the concentration of 6.5 muM [2].
  • Upon addition of frangulanine, mitochondria underwent swelling in 0.15 M KCl or RbCl solution but in neither NaCl nor LiCl solution [2].

Analytical, diagnostic and therapeutic context of Frangulanine

  • Bioassay-guided fractionation of this extract using separation by normal and reverse high-performance liquid chromatography (HPLC) resulted in the isolation of two active compounds identified as frangulanine, a cyclic peptide alkaloid, and waltherione-A, a quinolinone alkaloid [3].


  1. Metabolic cleavage of frangufoline in rodents: in vitro and in vivo study. Suh, D.Y., Kim, Y.C., Kang, Y.H., Han, Y.N., Han, B.H. J. Nat. Prod. (1997) [Pubmed]
  2. Biochemical studies on peptide alkaloids: induction of ion selective mitochondrial swelling. Kawai, K., Nozawa, Y., Ogihara, Y. Experientia (1977) [Pubmed]
  3. Bioassay-guided isolation of antifungal alkaloids from Melochia odorata. Emile, A., Waikedre, J., Herrenknecht, C., Fourneau, C., Gantier, J.C., Hnawia, E., Cabalion, P., Hocquemiller, R., Fournet, A. Phytotherapy research : PTR (2007) [Pubmed]
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