- Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation. Mandal, A.K., Lee, P., Chen, J.A., Nillegoda, N., Heller, A., Distasio, S., Oen, H., Victor, J., Nair, D.M., Brodsky, J.L., Caplan, A.J. J. Cell Biol. (2007)