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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Oncogene-induced senescence pathways weave an intricate tapestry.

The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38- regulated/ activated protein kinase ( PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.[1]


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