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MeSH Review

Skin Neoplasms

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Disease relevance of Skin Neoplasms


Psychiatry related information on Skin Neoplasms


High impact information on Skin Neoplasms


Chemical compound and disease context of Skin Neoplasms


Biological context of Skin Neoplasms


Anatomical context of Skin Neoplasms


Gene context of Skin Neoplasms

  • Stat3 is required for the development of skin cancer [26].
  • Two of them, ERCC2 and ERCC3, are responsible for atypical forms of XP disorders which confer a high predisposition to skin cancer [27].
  • Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk [28].
  • We also show that Xpc Trp53 double heterozygous mutants are more predisposed to skin cancer than Trp53 single heterozygous mice [29].
  • The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction [30].

Analytical, diagnostic and therapeutic context of Skin Neoplasms


  1. Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin. Kraemer, K.H., DiGiovanna, J.J., Moshell, A.N., Tarone, R.E., Peck, G.L. N. Engl. J. Med. (1988) [Pubmed]
  2. Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Aszterbaum, M., Epstein, J., Oro, A., Douglas, V., LeBoit, P.E., Scott, M.P., Epstein, E.H. Nat. Med. (1999) [Pubmed]
  3. Sunlight-induced basal cell carcinoma tumor cells and ultraviolet-B-irradiated psoriatic plaques express Fas ligand (CD95L). Gutierrez-Steil, C., Wrone-Smith, T., Sun, X., Krueger, J.G., Coven, T., Nickoloff, B.J. J. Clin. Invest. (1998) [Pubmed]
  4. Mortality risk from squamous cell skin cancer. Clayman, G.L., Lee, J.J., Holsinger, F.C., Zhou, X., Duvic, M., El-Naggar, A.K., Prieto, V.G., Altamirano, E., Tucker, S.L., Strom, S.S., Kripke, M.L., Lippman, S.M. J. Clin. Oncol. (2005) [Pubmed]
  5. A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. Winsey, S.L., Haldar, N.A., Marsh, H.P., Bunce, M., Marshall, S.E., Harris, A.L., Wojnarowska, F., Welsh, K.I. Cancer Res. (2000) [Pubmed]
  6. Xeroderma pigmentosum patients from Egypt: II. Preliminary correlations of epidemiology, clinical symptoms and molecular biology. Cleaver, J.E., Zelle, B., Hashem, N., El-Hefnawi, M.H., German, J. J. Invest. Dermatol. (1981) [Pubmed]
  7. Cutaneous malignancies and metastatic squamous cell carcinoma following topical therapies for mycosis fungoides. Abel, E.A., Sendagorta, E., Hoppe, R.T. J. Am. Acad. Dermatol. (1986) [Pubmed]
  8. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Muñoz, P., Blanco, R., Flores, J.M., Blasco, M.A. Nat. Genet. (2005) [Pubmed]
  9. Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition. van der Horst, G.T., van Steeg, H., Berg, R.J., van Gool, A.J., de Wit, J., Weeda, G., Morreau, H., Beems, R.B., van Kreijl, C.F., de Gruijl, F.R., Bootsma, D., Hoeijmakers, J.H. Cell (1997) [Pubmed]
  10. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. Hennekens, C.H., Buring, J.E., Manson, J.E., Stampfer, M., Rosner, B., Cook, N.R., Belanger, C., LaMotte, F., Gaziano, J.M., Ridker, P.M., Willett, W., Peto, R. N. Engl. J. Med. (1996) [Pubmed]
  11. More on skin cancer after the extravasation of doxorubicin. Silverman, H.I. N. Engl. J. Med. (1995) [Pubmed]
  12. Relation between skin cancer and HLA antigens in renal-transplant recipients. Bouwes Bavinck, J.N., Vermeer, B.J., van der Woude, F.J., Vandenbroucke, J.P., Schreuder, G.M., Thorogood, J., Persijn, G.G., Claas, F.H. N. Engl. J. Med. (1991) [Pubmed]
  13. Skin cancer and cyclosporine therapy. Price, M.L., Tidman, M.J., Ogg, C.S., MacDonald, D.M. N. Engl. J. Med. (1985) [Pubmed]
  14. Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer. Tornaletti, S., Pfeifer, G.P. Science (1994) [Pubmed]
  15. Recognition and repair of the cyclobutane thymine dimer, a major cause of skin cancers, by the human excision nuclease. Reardon, J.T., Sancar, A. Genes Dev. (2003) [Pubmed]
  16. Protective effects of silymarin against photocarcinogenesis in a mouse skin model. Katiyar, S.K., Korman, N.J., Mukhtar, H., Agarwal, R. J. Natl. Cancer Inst. (1997) [Pubmed]
  17. Low fidelity DNA synthesis by human DNA polymerase-eta. Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., Kunkel, T.A. Nature (2000) [Pubmed]
  18. Fas ligand: a sensor for DNA damage critical in skin cancer etiology. Hill, L.L., Ouhtit, A., Loughlin, S.M., Kripke, M.L., Ananthaswamy, H.N., Owen-Schaub, L.B. Science (1999) [Pubmed]
  19. Signature p53 mutation at DNA cross-linking sites in 8-methoxypsoralen and ultraviolet A (PUVA)-induced murine skin cancers. Nataraj, A.J., Black, H.S., Ananthaswamy, H.N. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  20. Photocarcinogenesis and inhibition of intercellular adhesion molecule 1 expression in cells of DNA-repair-defective individuals. Ahrens, C., Grewe, M., Berneburg, M., Grether-Beck, S., Quilliet, X., Mezzina, M., Sarasin, A., Lehmann, A.R., Arlett, C.F., Krutmann, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  21. Antigenic similarity between cells transformed by ultraviolet radiation in vitro and in vivo. Fisher, M.S., Kripke, M.L., Chan, G.L. Science (1984) [Pubmed]
  22. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Sano, S., Chan, K.S., Kira, M., Kataoka, K., Takagi, S., Tarutani, M., Itami, S., Kiguchi, K., Yokoi, M., Sugasawa, K., Mori, T., Hanaoka, F., Takeda, J., DiGiovanni, J. Cancer Res. (2005) [Pubmed]
  23. Role of G protein-coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin 1 receptors. Sánchez-Más, J., Guillo, L.A., Zanna, P., Jiménez-Cervantes, C., García-Borrón, J.C. Mol. Endocrinol. (2005) [Pubmed]
  24. Effect of nonsense mutations on PTEN mRNA stability. Raizis, A.M., Ferguson, M.M., George, P.M. Hum. Genet. (2000) [Pubmed]
  25. Dietary L-histidine regulates murine skin levels of trans-urocanic acid, an immune-regulating photoreceptor, with an unanticipated modulation: potential relevance to skin cancer. De Fabo, E.C., Webber, L.J., Ulman, E.A., Broemeling, L.D. J. Nutr. (1997) [Pubmed]
  26. Stat3 is required for the development of skin cancer. Pedranzini, L., Leitch, A., Bromberg, J. J. Clin. Invest. (2004) [Pubmed]
  27. The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor. Schaeffer, L., Moncollin, V., Roy, R., Staub, A., Mezzina, M., Sarasin, A., Weeda, G., Hoeijmakers, J.H., Egly, J.M. EMBO J. (1994) [Pubmed]
  28. Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. Beaumont, K.A., Newton, R.A., Smit, D.J., Leonard, J.H., Stow, J.L., Sturm, R.A. Hum. Mol. Genet. (2005) [Pubmed]
  29. Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors. Cheo, D.L., Meira, L.B., Burns, D.K., Reis, A.M., Issac, T., Friedberg, E.C. Cancer Res. (2000) [Pubmed]
  30. The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction. Nelson, H.H., Kelsey, K.T., Mott, L.A., Karagas, M.R. Cancer Res. (2002) [Pubmed]
  31. Retinoid protection against x-ray-induced chromatid damage in human peripheral blood lymphocytes. Sanford, K.K., Parshad, R., Price, F.M., Tarone, R.E., Kraemer, K.H. J. Clin. Invest. (1992) [Pubmed]
  32. Human papillomavirus type 5 and skin cancer in renal allograft recipients. Bunney, M.H., Barr, B.B., McLaren, K., Smith, I.W., Benton, E.C., Anderton, J.L., Hunter, J.A. Lancet (1987) [Pubmed]
  33. Immunosuppression by ultraviolet B radiation: initiation by urocanic acid. Noonan, F.P., De Fabo, E.C. Immunol. Today (1992) [Pubmed]
  34. Activation of JNK and p38 but not ERK MAP kinases in human skin cells by 5-aminolevulinate-photodynamic therapy. Klotz, L.O., Fritsch, C., Briviba, K., Tsacmacidis, N., Schliess, F., Sies, H. Cancer Res. (1998) [Pubmed]
  35. Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors. Germolec, D.R., Spalding, J., Yu, H.S., Chen, G.S., Simeonova, P.P., Humble, M.C., Bruccoleri, A., Boorman, G.A., Foley, J.F., Yoshida, T., Luster, M.I. Am. J. Pathol. (1998) [Pubmed]
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