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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Aging

 
 
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Disease relevance of Aging

 

Psychiatry related information on Aging

 

High impact information on Aging

  • At the cellular level, p53 induces apoptosis, cell cycle arrest and senescence [11].
  • A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy [12].
  • We identified bes1, a semidominant suppressor of bri1, which exhibits constitutive BR response phenotypes including long and bending petioles, curly leaves, accelerated senescence, and constitutive expression of BR-response genes [13].
  • Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers [14].
  • In addition, expression of mutant forms of TRF2 induced a growth arrest with characteristics of senescence [15].
 

Chemical compound and disease context of Aging

  • Src expression increased drug survival in HT1080 fibrosarcoma cells, as measured by the colony formation assay, and strongly inhibited Adriamycin-induced senescence [16].
  • These concentrations of ceramide also induced retinoblastoma dephosphorylation and inhibited serum-induced AP-1 activation in young HDF, thus recapitulating basic biochemical and molecular changes of senescence [17].
  • Expression of ipt, a cytokinin biosynthetic gene from Agrobacterium tumefaciens, under the control of the promoter from a senescence-associated gene (SAG12) has been one approach used to delay senescence [18].
  • METHODS: Several different chronic conditions were studied in rats: senescence, hypertension, chronic hypoxia, and administration of thyroid hormone [19].
  • The results suggest that both ABA and cytokinins are involved in controlling plant senescence, and an enhanced carbon remobilization is attributed to an elevated ABA level in rice plants subjected to water stress [20].
 

Biological context of Aging

 

Anatomical context of Aging

 

Associations of Aging with chemical compounds

 

Gene context of Aging

  • Thus, Cdk4 deficiency causes senescence in a unique Arf/p53-independent manner, which accounts for the loss of transformation potential [36].
  • A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling [37].
  • We made a large library containing random mutations in the amino terminus of the EST2 gene, which encodes the Saccharomyces cerevisiae TERT, and selected functional alleles by their ability to rescue senescence of telomerase-negative cells [38].
  • Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform [39].
  • WS fibroblasts display defects associated with telomere dysfunction, including accelerated telomere erosion and premature senescence [40].
 

Analytical, diagnostic and therapeutic context of Aging

References

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