Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Roh, J.L. et al.

Jong-Lyel Roh, Chang Hwan Ryu, Seung-Ho Choi, Jae Seung Kim, Jeong Hyun Lee, Kyung-Ja Cho, Soon Yuhl Nam, Sang Yoon Kim,

Clinical utility of 18F-FDG PET for patients with salivary gland malignancies.

The clinical utility of 18F-FDG PET in evaluating salivary gland malignancies has not been well defined. We therefore evaluated the utility of 18F-FDG PET in management for patients with salivary gland cancers. METHODS: Thirty-four patients with newly diagnosed salivary gland cancers underwent CT and 18F-FDG PET before surgical resection with radiotherapy. The diagnostic accuracies of CT and 18F-FDG PET for detecting primary tumors and neck metastases were compared with a histopathologic reference. We determined the relationship between the maximum standardized uptake value (SUV) of the tumor and clinicopathologic parameters such as sex, age, local tumor invasion, T and N categories, TNM stage, and histologic grade, as well as their associations with disease-free survival (DFS). RESULTS: 18F-FDG PET was more sensitive than CT for the detection of primary tumors (91.2% vs. 79.4%; P < 0.05), cervical metastases (80.5% vs. 56.1%; P < 0.05), and distant metastases in 2 patients at initial staging. High-grade malignancies had higher mean maximum SUVs than did low- and intermediate-grade malignancies (4.6 vs. 2.8; P = 0.011). T and N categories were independent determinants of DFS (P < 0.05), but the maximum SUV (4.0) was not. During a mean follow-up of 25.1 mo, 18F-FDG PET correctly diagnosed local-regional recurrences in 6 patients and new distant metastases in 9 patients. CONCLUSION: Our findings indicate that, in patients with salivary gland malignancies, 18F-FDG PET is clinically useful in initial staging, histologic grading, and monitoring after treatment but not in predicting patient survival.[1]

References

Clinical utility of 18F-FDG PET for patients with salivary gland malignancies. Roh, J.L., Ryu, C.H., Choi, S.H., Kim, J.S., Lee, J.H., Cho, K.J., Nam, S.Y., Kim, S.Y. J. Nucl. Med. (2007) [Pubmed]

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