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Chemical Compound Review:

18F-FDG (2S,3R,4S,5S,6R)-3-fluoro-6...

Synonyms: Flucis, SureCN135994, CHEBI:31617, MOLI000964, AC1L9OYT, ...

Seidenwurm, D. et al., Chung, A. et al., Pauleit, D. et al., Shammas, A. et al., Lee, S.J. et al., et al.

Andre Zimmermann, Liebovitz, Shinji Abe, Mitsuru Ikeda, Hidetoshi Kobayashi, Takeo Ishigaki, Jong-Lyel Roh, Masanori Tadokoro, Goy, Turlakow, H. William Strauss, Shmuel Rispler, Avi Bar-Shalev, Rudi A. Dierckx, Yeung, Rachel Bar-Shalom, Larson, Heinz H. Coenen, Jörn Risse, Pui, Kurt Hamacher, Kazuhiro Shiba, Satoshi Nakano, Gabriele Stoffels, Aren van Waarde, Toshinobu Kubota, Dirk Pauleit, Rusch, Jae Seung Kim, Jeong Hyun Lee, Kyung-Ja Cho, Michael O. Flüss, Zohar Keidar, Katsuhiko Kato, Dagmar Bauer, Chang Hwan Ryu, Masanari Nishino, Johan R. de Jong, Macapinlac, Sang Yoon Kim, Ora Israel, Philip H. Elsinga, Michal Weiler-Sagie, Kiichi Ishiwata, Karl-Josef Langen, Alex Frenkel, Soon Yuhl Nam, Seung-Ho Choi,

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Disease relevance of Fludeoxyglucose F 18

Diagnosis of recurrent astrocytoma with fludeoxyglucose F18 PET scanning [1].
Fludeoxyglucose positron emission tomography in the diagnosis of giant cell arteritis [2].
MAIN OUTCOME MEASURES: Axillary FDG activity, quantified by standardized uptake value (SUV); axillary metastases, quantified histologically; and tumor characteristics [3].
18F-FET may not replace 18F-FDG in the PET diagnostics of head and neck cancer but may be a helpful additional tool in selected patients, because 18F-FET PET might better differentiate tumor tissue from inflammatory tissue [4].
8 of 9 patients with uveal malignant melanoma showed false-negative results in 18F-FDG PET [5].
During a mean follow-up of 25.1 mo, 18F-FDG PET correctly diagnosed local-regional recurrences in 6 patients and new distant metastases in 9 patients [6].
Both 11C-SA4503 binding and 18F-FDG uptake declined in gliomas after chemotherapy [7].
SUV measurements may provide valuable information about the state of ER, PR, and C-erbB-2R and the associated glucose metabolism as measured by 18F-FDG uptake of the primary breast cancer lesions [8].

High impact information on Fludeoxyglucose F 18

CONCLUSIONS: Global or absolute measures of metabolism using positron emission tomography and fludeoxyglucose F18 did not statistically differentiate between normal adolescents with ADHD [9].
Of the publications retrieved by these text words, only 4% were indexed by the MeSH term "Fludeoxyglucose F18" in Medline and 29% by the MeSH-term "Fluorodeoxyglucose F18" in Embase [10].
METHODS: Seven subjects with histories of extremely violent behavior were studied with positron emission tomography (PET) with fludeoxyglucose F 18 (FDG), brain electrical area mapping, MR imaging, neuropsychiatric and neuropsychological testing, and clinical examination during medical evaluation associated with legal proceedings [11].

Psychiatry related information on Fludeoxyglucose F 18

Our study demonstrated that vascular 18F-FDG uptake is reversed in response to atherogenic risk reduction by lifestyle intervention and that the magnitude of improvement correlates to increases in plasma HDL levels [12].

Chemical compound and disease context of Fludeoxyglucose F 18

HYPOTHESIS: Fludeoxyglucose F 18 (FDG) positron emission tomography (PET) can be used to predict axillary node metastases [3].

Associations of Fludeoxyglucose F 18 with other chemical compounds

The findings of this study suggest that further assessment of 131I WBS-negative, thyroglobulin-positive patients by 18F-FDG PET/CT may aid in the clinical management of selected cases regardless of the thyroglobulin level [13].
Cardiac 18F-FDG uptake was lower in patients receiving bezafibrate and levothyroxine and higher in patients receiving benzodiazepines [14].

References

Diagnosis of recurrent astrocytoma with fludeoxyglucose F18 PET scanning. Mirzaei, S., Knoll, P., Kohn, H. N. Engl. J. Med. (2001) [Pubmed]
Fludeoxyglucose positron emission tomography in the diagnosis of giant cell arteritis. Turlakow, A., Yeung, H.W., Pui, J., Macapinlac, H., Liebovitz, E., Rusch, V., Goy, A., Larson, S.M. Arch. Intern. Med. (2001) [Pubmed]
Preoperative FDG-PET for axillary metastases in patients with breast cancer. Chung, A., Liou, D., Karlan, S., Waxman, A., Fujimoto, K., Hagiike, M., Phillips, E.H. Archives of surgery (Chicago, Ill. : 1960) (2006) [Pubmed]
18F-FET PET compared with 18F-FDG PET and CT in patients with head and neck cancer. Pauleit, D., Zimmermann, A., Stoffels, G., Bauer, D., Risse, J., Flüss, M.O., Hamacher, K., Coenen, H.H., Langen, K.J. J. Nucl. Med. (2006) [Pubmed]
Low efficacy of 18F-FDG PET for detection of uveal malignant melanoma compared with 123I-IMP SPECT. Kato, K., Kubota, T., Ikeda, M., Tadokoro, M., Abe, S., Nakano, S., Nishino, M., Kobayashi, H., Ishigaki, T. J. Nucl. Med. (2006) [Pubmed]
Clinical utility of 18F-FDG PET for patients with salivary gland malignancies. Roh, J.L., Ryu, C.H., Choi, S.H., Kim, J.S., Lee, J.H., Cho, K.J., Nam, S.Y., Kim, S.Y. J. Nucl. Med. (2007) [Pubmed]
Rapid reduction of sigma1-receptor binding and 18F-FDG uptake in rat gliomas after in vivo treatment with doxorubicin. van Waarde, A., Shiba, K., de Jong, J.R., Ishiwata, K., Dierckx, R.A., Elsinga, P.H. J. Nucl. Med. (2007) [Pubmed]
The effects of estrogen, progesterone, and C-erbB-2 receptor states on 18F-FDG uptake of primary breast cancer lesions. Mavi, A., Cermik, T.F., Urhan, M., Puskulcu, H., Basu, S., Yu, J.Q., Zhuang, H., Czerniecki, B., Alavi, A. J. Nucl. Med. (2007) [Pubmed]
Brain metabolism in teenagers with attention-deficit hyperactivity disorder. Zametkin, A.J., Liebenauer, L.L., Fitzgerald, G.A., King, A.C., Minkunas, D.V., Herscovitch, P., Yamada, E.M., Cohen, R.M. Arch. Gen. Psychiatry (1993) [Pubmed]
How to perform a comprehensive search for FDG-PET literature. Mijnhout, G.S., Hooft, L., van Tulder, M.W., Devillé, W.L., Teule, G.J., Hoekstra, O.S. European journal of nuclear medicine. (2000) [Pubmed]
Abnormal temporal lobe metabolism in violent subjects: correlation of imaging and neuropsychiatric findings. Seidenwurm, D., Pounds, T.R., Globus, A., Valk, P.E. AJNR. American journal of neuroradiology. (1997) [Pubmed]
Reversal of vascular 18F-FDG uptake with plasma high-density lipoprotein elevation by atherogenic risk reduction. Lee, S.J., On, Y.K., Lee, E.J., Choi, J.Y., Kim, B.T., Lee, K.H. J. Nucl. Med. (2008) [Pubmed]
18F-FDG PET/CT in patients with suspected recurrent or metastatic well-differentiated thyroid cancer. Shammas, A., Degirmenci, B., Mountz, J.M., McCook, B.M., Branstetter, B., Bencherif, B., Bencherif, B.B., Joyce, J.M., Carty, S.E., Kuffner, H.A., Avril, N. J. Nucl. Med. (2007) [Pubmed]
PET/CT quantitation of the effect of patient-related factors on cardiac 18F-FDG uptake. Israel, O., Weiler-Sagie, M., Rispler, S., Bar-Shalom, R., Frenkel, A., Keidar, Z., Bar-Shalev, A., Strauss, H.W. J. Nucl. Med. (2007) [Pubmed]

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