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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of oral contraceptives on plasma clearance.

The effects of chronic steroid contraceptive therapy on drug clearance from plasma were studied by using plasma antipyrine, phenylbutazone, and cholecalciferol half-lives in women. After 3 mo of oral steroid therapy (Norinyl, 2 mg; norethindrone + mestranol), the antipyrine half-life was increased in 3 of 6 subjects, phenylbutazone half-life was not consistently altered, and vitamin D3 half-life was increased in 3 of 4 patients. After 1 to 7 yr of oral steroid theraphy, the antipyrine half-life was longer while taking the contraceptive than when the contraceptive treatment was discontinued in 4 of 6 subjects, whereas that of phenylbutazone was not consistently altered.[1]


  1. Effect of oral contraceptives on plasma clearance. Carter, D.E., Bressler, R., Hughes, M.R., Haussler, M.R., Christian, D., Heine, M.W. Clin. Pharmacol. Ther. (1975) [Pubmed]
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