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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Agmatine blocks morphine-evoked hyperthermia in rats.

The present study investigated the effect of agmatine on morphine-evoked hyperthermia in rats. Morphine (4 mg/kg, s.c.) produced hyperthermia by activating mu opioid receptors. Agmatine (10 and 50 mg/kg, i.p.) was ineffective. For combined administration, agmatine decreased morphine-evoked hyperthermia. The effect was prevented by idazoxan (5 mg/kg, i.p.), an imidazoline/alpha(2)-adrenoeceptor receptor antagonist. Yohimbine, an alpha(2)-adrenoeceptor antagonist, did not prevent the attenuation of morphine-evoked hyperthermia by agmatine. The present data provide pharmacological evidence that agmatine blocks the hyperthermic effect of morphine by activating imidazoline receptors.[1]


  1. Agmatine blocks morphine-evoked hyperthermia in rats. Rawls, S.M., Amin, M., Zisk, J. Brain Res. (2007) [Pubmed]
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