Chemical Compound Review:
agmatine 2-(4-aminobutyl)guanidine
Synonyms:
Argmatine, AmbotzHNN1040, Lopac-A-7127, Tocris-0842, CHEMBL58343, ...
Satriano,
Matsufuji,
Murakami,
Lortie,
Schwartz,
Kelly,
Hayashi,
Blantz,
Horváth,
Kékesi,
Dobos,
Szikszay,
Klimscha,
Benedek,
Rawls,
Tallarida,
Zisk,
Uzbay,
Yeşilyurt,
Celik,
Ergün,
Işimer,
Nissim,
Horyn,
Daikhin,
Nissim,
Luhovyy,
Phillips,
Yudkoff,
Reis,
Regunathan,
Satriano,
Schwartz,
Ishizuka,
Lortie,
Thomson,
Gabbai,
Kelly,
Blantz,
Gründemann,
Hahne,
Berkels,
Schömig,
- Is agmatine a novel neurotransmitter in brain? Reis, D.J., Regunathan, S. Trends Pharmacol. Sci. (2000)
- Biosynthesis of polyamines in ornithine decarboxylase, arginine decarboxylase, and agmatine ureohydrolase deletion mutants of Escherichia coli strain K-12. Panagiotidis, C.A., Blackburn, S., Low, K.B., Canellakis, E.S. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Characterization of mouse Rt6.1 NAD:arginine ADP-ribosyltransferase. Moss, J., Stevens, L.A., Cavanaugh, E., Okazaki, I.J., Bortell, R., Kanaitsuka, T., Mordes, J.P., Greiner, D.L., Rossini, A.A. J. Biol. Chem. (1997)
- Methanococcus jannaschii uses a pyruvoyl-dependent arginine decarboxylase in polyamine biosynthesis. Graham, D.E., Xu, H., White, R.H. J. Biol. Chem. (2002)
- N1-aminopropylagmatine, a new polyamine produced as a key intermediate in polyamine biosynthesis of an extreme thermophile, Thermus thermophilus. Ohnuma, M., Terui, Y., Tamakoshi, M., Mitome, H., Niitsu, M., Samejima, K., Kawashima, E., Oshima, T. J. Biol. Chem. (2005)
- IRAS, a candidate for I1-imidazoline receptor, mediates inhibitory effect of agmatine on cellular morphine dependence. Wu, N., Su, R.B., Xu, B., Lu, X.Q., Liu, Y., Zheng, J.Q., Piletz, J.E., Li, J., Qin, B.Y. Biochem. Pharmacol. (2005)
- Effect of intrathecal agmatine on inflammation-induced thermal hyperalgesia in rats. Horváth, G., Kékesi, G., Dobos, I., Szikszay, M., Klimscha, W., Benedek, G. Eur. J. Pharmacol. (1999)
- Agmatine and a cannabinoid agonist, WIN 55212-2, interact to produce a hypothermic synergy. Rawls, S.M., Tallarida, R.J., Zisk, J. Eur. J. Pharmacol. (2006)
- Effects of agmatine on ethanol withdrawal syndrome in rats. Uzbay, I.T., Yeşilyurt, O., Celik, T., Ergün, H., Işimer, A. Behav. Brain Res. (2000)
- Anxiolytic effect of agmatine in rats and mice. Gong, Z.H., Li, Y.F., Zhao, N., Yang, H.J., Su, R.B., Luo, Z.P., Li, J. Eur. J. Pharmacol. (2006)
- Agmatine: an endogenous clonidine-displacing substance in the brain. Li, G., Regunathan, S., Barrow, C.J., Eshraghi, J., Cooper, R., Reis, D.J. Science (1994)
- Imidazoline receptors and their endogenous ligands. Regunathan, S., Reis, D.J. Annu. Rev. Pharmacol. Toxicol. (1996)
- Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat. Lortie, M.J., Novotny, W.F., Peterson, O.W., Vallon, V., Malvey, K., Mendonca, M., Satriano, J., Insel, P., Thomson, S.C., Blantz, R.C. J. Clin. Invest. (1996)
- Agmatine transport into spinal nerve terminals is modulated by polyamine analogs. Goracke-Postle, C.J., Overland, A.C., Stone, L.S., Fairbanks, C.A. J. Neurochem. (2007)
- Suppression of inducible nitric oxide generation by agmatine aldehyde: beneficial effects in sepsis. Satriano, J., Schwartz, D., Ishizuka, S., Lortie, M.J., Thomson, S.C., Gabbai, F., Kelly, C.J., Blantz, R.C. J. Cell. Physiol. (2001)
- Metabolic pathway for the utilization of L-arginine, L-ornithine, agmatine, and putrescine as nitrogen sources in Escherichia coli K-12. Shaibe, E., Metzer, E., Halpern, Y.S. J. Bacteriol. (1985)
- Central cardiovascular actions of agmatine, a putative clonidine-displacing substance, in conscious rabbits. Head, G.A., Chan, C.K., Godwin, S.J. Neurochem. Int. (1997)
- Molecular characterization and regulation of the aguBA operon, responsible for agmatine utilization in Pseudomonas aeruginosa PAO1. Nakada, Y., Jiang, Y., Nishijyo, T., Itoh, Y., Lu, C.D. J. Bacteriol. (2001)
- Ifosfamide-induced nephrotoxicity: mechanism and prevention. Nissim, I., Horyn, O., Daikhin, Y., Nissim, I., Luhovyy, B., Phillips, P.C., Yudkoff, M. Cancer Res. (2006)
- Agmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levels. Satriano, J., Matsufuji, S., Murakami, Y., Lortie, M.J., Schwartz, D., Kelly, C.J., Hayashi, S., Blantz, R.C. J. Biol. Chem. (1998)
- A bacterial arginine-agmatine exchange transporter involved in extreme Acid resistance. Fang, Y., Kolmakova-Partensky, L., Miller, C. J. Biol. Chem. (2007)
- Agmatine stimulates hepatic fatty acid oxidation: a possible mechanism for up-regulation of ureagenesis. Nissim, I., Daikhin, Y., Nissim, I., Luhovyy, B., Horyn, O., Wehrli, S.L., Yudkoff, M. J. Biol. Chem. (2006)
- Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. Fairbanks, C.A., Schreiber, K.L., Brewer, K.L., Yu, C.G., Stone, L.S., Kitto, K.F., Nguyen, H.O., Grocholski, B.M., Shoeman, D.W., Kehl, L.J., Regunathan, S., Reis, D.J., Yezierski, R.P., Wilcox, G.L. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Agmatine inhibits cell proliferation and improves renal function in anti-thy-1 glomerulonephritis. Ishizuka, S., Cunard, R., Poucell-Hatton, S., Wead, L., Lortie, M., Thomson, S.C., Gabbai, F.B., Satriano, J., Blantz, R.C. J. Am. Soc. Nephrol. (2000)
- Activation of imidazoline receptors in adrenal gland to lower plasma glucose in streptozotocin-induced diabetic rats. Hwang, S.L., Liu, I.M., Tzeng, T.F., Cheng, J.T. Diabetologia (2005)
- Enhancement of choleragen ADP-ribosyltransferase activities by guanyl nucleotides and a 19-kDa membrane protein. Tsai, S.C., Noda, M., Adamik, R., Moss, J., Vaughan, M. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Regulation of arginine metabolism in Saccharomyces cerevisiae. Association of arginase and ornithine transcarbamoylase. Eisenstein, E., Duong, L.T., Ornberg, R.L., Osborne, J.C., Hensley, P. J. Biol. Chem. (1986)
- Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokines. Sastre, M., Galea, E., Feinstein, D., Reis, D.J., Regunathan, S. Biochem. J. (1998)
- Influence of cyclic AMP, agmatine, and a novel protein encoded by a flanking gene on speB (agmatine ureohydrolase) in Escherichia coli. Szumanski, M.B., Boyle, S.M. J. Bacteriol. (1992)
- Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). Gründemann, D., Hahne, C., Berkels, R., Schömig, E. J. Pharmacol. Exp. Ther. (2003)
- Inactivation of platelet-derived growth factor-BB following modification by ADP-ribosyltransferase. Saxty, B.A., Yadollahi-Farsani, M., Upton, P.D., Johnstone, S.R., MacDermot, J. Br. J. Pharmacol. (2001)
- Improved method for HPLC analysis of polyamines, agmatine and aromatic monoamines in plant tissue. Slocum, R.D., Flores, H.E., Galston, A.W., Weinstein, L.H. Plant Physiol. (1989)
- Agmatine potentiates the analgesic effect of morphine by an alpha(2)-adrenoceptor-mediated mechanism in mice. Yeşilyurt, O., Uzbay, I.T. Neuropsychopharmacology (2001)
- Agmatine inhibits the proliferation of rat hepatoma cells by modulation of polyamine metabolism. Gardini, G., Cravanzola, C., Autelli, R., Testore, G., Cesa, R., Morando, L., Solinas, S.P., Muzio, G., Grillo, M.A., Colombatto, S. J. Hepatol. (2003)