Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Huntington, N.D. et al.

Nicholas D. Huntington, Hy Tabarias, Kirsten Fairfax, Jason Brady, Yoshihiro Hayakawa, Mariapia A. Degli-Esposti, Mark J. Smyth, David M. Tarlinton, Stephen L. Nutt,

NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation.

NK cells are important for the clearance of tumors, parasites, and virus-infected cells. Thus, factors that control NK cell numbers and function are critical for the innate immune response. A subset of NK cells express the inhibitory killer cell lectin-like receptor G1 (KLRG1). In this study, we identify that KLRG1 expression is acquired during periods of NK cell division such as development and homeostatic proliferation. KLRG1(+) NK cells are mature in phenotype, and we show for the first time that these cells have a slower in vivo turnover rate, reduced proliferative response to IL-15, and poorer homeostatic expansion potential compared with mature NK cells lacking KLRG1. Transfer into lymphopenic recipients indicate that KLRG1(-) NK cells are precursors of KLRG1(+) NK cells and KLRG1 expression accumulates following cell division. Furthermore, KLRG1(+) NK cells represent a significantly greater proportion of NK cells in mice with enhanced NK cell numbers such as Cd45(-/-) mice. These data indicate that NK cells acquire KLRG1 on their surface during development, and this expression correlates with functional distinctions from other peripheral NK cells in vivo.[1]

References

NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. Huntington, N.D., Tabarias, H., Fairfax, K., Brady, J., Hayakawa, Y., Degli-Esposti, M.A., Smyth, M.J., Tarlinton, D.M., Nutt, S.L. J. Immunol. (2007) [Pubmed]

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