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Jiang, Z. et al.

Zhihua Jiang, Zeping Wang, Tanja Kunej, Galen A. Williams, Jennifer J. Michal, Xiao-Lin Wu, Nancy S. Magnuson,

A novel type of sequence variation: multiple-nucleotide length polymorphisms discovered in the bovine genome.

Three types of sequence variations--single-nucleotide polymorphisms (SNPs), insertions and deletions (indels), and short tandem repeats (STRs)--have been extensively reported in mammalian genomes. In this study, we discovered a novel type of sequence variation, i.e., multiple-nucleotide length polymorphisms (MNLPs) in bovine UCN3 (Urocortin 3) and its receptor CRHR2 (corticotropin-releasing hormone receptor 2) genes. Both MNLPs featured involvement of multiple-nucleotide length polymorphisms (5-18 bases), low sequence identity, and 1.7- to 11-fold changes in promoter activity between two alleles. Therefore, this novel genetic complexity would contribute significantly to the evolutionary, functional, and phenotypic complexity of genomes within or among species.[1]

References

A novel type of sequence variation: multiple-nucleotide length polymorphisms discovered in the bovine genome. Jiang, Z., Wang, Z., Kunej, T., Williams, G.A., Michal, J.J., Wu, X.L., Magnuson, N.S. Genetics (2007) [Pubmed]

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