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Centonze, D. et al.

Diego Centonze, Silvia Rossi, Chiara Prosperetti, Valeria Gasperi, Valentina De Chiara, Monica Bari, Anne Tscherter, Fabia Febbraro, Giorgio Bernardi, Mauro Maccarrone,

Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons.

Synaptic transmission in the striatum is regulated by metabotropic glutamate (mGlu) receptors through pre- and postsynaptic mechanisms. We investigated the involvement of mGlu 1 and 5 receptors in the control of both excitatory and inhibitory transmission in the striatum. The mGlu 1 and 5 receptor agonist 3,5-DHPG failed to affect glutamate transmission, while it caused a biphasic effect on GABA transmission, characterized by early increase and late decrease in the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) recorded from striatal principal neurons. Both mGlu 1 and 5 receptors were involved in the early response to 3,5-DHPG, through membrane depolarization of striatal GABAergic interneurons and action potential generation. The 3,5-DHPG-mediated late depression of inhibitory inputs to striatal principal neurons was conversely secondary to mGlu 5 receptor activation and subsequent endocannabinoid release. In conclusion, we have identified an mGlu-dependent mechanism of GABA transmission regulation of potential relevance for physiological neuronal activity.[1]

References

Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons. Centonze, D., Rossi, S., Prosperetti, C., Gasperi, V., De Chiara, V., Bari, M., Tscherter, A., Febbraro, F., Bernardi, G., Maccarrone, M. Mol. Cell. Neurosci. (2007) [Pubmed]

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