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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Antiretroviral management of treatment-naive patients.

Antiretroviral management of treatment-naive patients begins with the decision of when to start treatment. Current treatment guidelines suggest starting therapy in anyone with AIDS, HIV-related symptoms, or a CD4 cell count less than 200/mm3 regardless of symptoms. Starting treatment in asymptomatic patients with CD4 of more than 200 requires consideration of a number of pros and cons, and individualization is the key. Recommended first-line antiretroviral regimens consist of two nucleoside reverse transcriptase inhibitors together with either a nonnucleoside reverse transcriptase inhibitor or a protease inhibitor (with or without ritonavir boosting). The goal of antiretroviral therapy is maximally to suppress viremia, enhance or improve immune function, and prevent clinical progression.[1]


  1. Antiretroviral management of treatment-naive patients. Gulick, R.M. Infect. Dis. Clin. North Am. (2007) [Pubmed]
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