Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Todd, J.A. et al.

John A. Todd, Neil M. Walker, Jason D. Cooper, Deborah J. Smyth, Kate Downes, Vincent Plagnol, Rebecca Bailey, Sergey Nejentsev, Sarah F. Field, Felicity Payne, Christopher E. Lowe, Jeffrey S. Szeszko, Jason P. Hafler, Lauren Zeitels, Jennie H. M. Yang, Adrian Vella, Sarah Nutland, Helen E. Stevens, Helen Schuilenburg, Gillian Coleman, Meeta Maisuria, William Meadows, Luc J. Smink, Barry Healy, Oliver S. Burren, Alex A. C. Lam, Nigel R. Ovington, James Allen, Ellen Adlem, Hin-Tak Leung, Chris Wallace, Joanna M. M. Howson, Cristian Guja, Constantin Ionescu-Tîrgovişte, Matthew J. Simmonds, Joanne M. Heward, Stephen C. L. Gough, David B. Dunger, Linda S. Wicker, David G. Clayton,

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P < 5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up) <or= 1.35 x 10(-9); P(overall) <or= 1.15 x 10(-14)), leaving eight regions with small effects or false-positive associations. We also obtained evidence for chromosome 18q22 (P(overall) = 1.38 x 10(-8)) from a GWA study of nonsynonymous SNPs. Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten.[1]

References

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Todd, J.A., Walker, N.M., Cooper, J.D., Smyth, D.J., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., Field, S.F., Payne, F., Lowe, C.E., Szeszko, J.S., Hafler, J.P., Zeitels, L., Yang, J.H., Vella, A., Nutland, S., Stevens, H.E., Schuilenburg, H., Coleman, G., Maisuria, M., Meadows, W., Smink, L.J., Healy, B., Burren, O.S., Lam, A.A., Ovington, N.R., Allen, J., Adlem, E., Leung, H.T., Wallace, C., Howson, J.M., Guja, C., Ionescu-Tîrgovişte, C., Simmonds, M.J., Heward, J.M., Gough, S.C., Dunger, D.B., Wicker, L.S., Clayton, D.G. Nat. Genet. (2007) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.