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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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HLA-G in B-chronic lymphocytic leukaemia: clinical relevance and functional implications.

HLA-G appears to be involved in regulatory functions counteracting the cellular immune response of T and NK cells by several pathways. We here summarize the HLA-G expression patterns in leukaemia with emphasis on the clinical relevance of this expression for disease progression. Especially in patients with B-chronic lymphocytic leukaemia (B-CLL) the HLA-G expression on B-CLL cells was strongly associated with a reduced treatment-free survival. The corresponding immunological parameters point to a broad immunosuppression in these patients. Thus, HLA-G seems to contribute to the impaired immune response in B-CLL supporting disease progression.[1]

References

  1. HLA-G in B-chronic lymphocytic leukaemia: clinical relevance and functional implications. Rebmann, V., Nückel, H., Dührsen, U., Grosse-Wilde, H. Semin. Cancer Biol. (2007) [Pubmed]
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