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MeSH Review

Immunity, Cellular

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  • CD1 proteins are conserved in all mammalian species so far examined and are prominently expressed on cells involved in antigen presentation, which suggests a role in activation of cell-mediated immunity [9].
  • CD40 and CD154 in cell-mediated immunity [10].
  • Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated immunity [11].
  • Antibodies on the surface of schizont-infected cells could facilitate binding of effector cells and trigger O2- release, thereby acting synergistically with cell-mediated immunity [12].
  • Inherited traits, such as abnormal hemoglobins and G-6-PD deficiency, and acquired cell-mediated immunity both subject malaria parasites to oxidant stress and may reinforce one another, increasing the chances of survival of children bearing these traits during the dangerous years of first exposure to malaria in areas where the disease is endemic [12].

Chemical compound and disease context of Immunity, Cellular


Biological context of Immunity, Cellular


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Associations of Immunity, Cellular with chemical compounds


Gene context of Immunity, Cellular

  • The identification of mutations in CXCR4 in individuals with WHIM syndrome represents the first example of aberrant chemokine receptor function causing human disease and suggests that the receptor may be important in cell-mediated immunity to HPV infection [33].
  • These mice will be useful in defining differences in inflammatory conditions and cellular immunity mediated by IL-10 [34].
  • These results suggest that IL-4 may regulate development and function of T-cell subsets involved in cell-mediated immunity in part by inhibiting factors required for transcription of the IL2 gene [35].
  • The reduced production of IL-15 from CB MNCs in response to stimulation may contribute to the decrease in IFN-gamma and TNF-alpha production and CB cellular immunity [36].
  • Type I IFN regulates different aspects of the immune response, inducing a cell-mediated immunity [37].

Analytical, diagnostic and therapeutic context of Immunity, Cellular


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  11. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Gately, M.K., Renzetti, L.M., Magram, J., Stern, A.S., Adorini, L., Gubler, U., Presky, D.H. Annu. Rev. Immunol. (1998) [Pubmed]
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  18. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Salgame, P., Abrams, J.S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R.L., Bloom, B.R. Science (1991) [Pubmed]
  19. Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire. Muraro, P.A., Vergelli, M., Kalbus, M., Banks, D.E., Nagle, J.W., Tranquill, L.R., Nepom, G.T., Biddison, W.E., McFarland, H.F., Martin, R. J. Clin. Invest. (1997) [Pubmed]
  20. Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity. Smiley, S.T., Boyer, S.N., Heeb, M.J., Griffin, J.H., Grusby, M.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  21. Inhibition of the defense system stimulating interleukin-12 interferon-gamma pathway during critical Illness. Ertel, W., Keel, M., Neidhardt, R., Steckholzer, U., Kremer, J.P., Ungethuem, U., Trentz, O. Blood (1997) [Pubmed]
  22. Hematopoietic remodeling in interferon-gamma-deficient mice infected with mycobacteria. Murray, P.J., Young, R.A., Daley, G.Q. Blood (1998) [Pubmed]
  23. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1. Gu, L., Tseng, S., Horner, R.M., Tam, C., Loda, M., Rollins, B.J. Nature (2000) [Pubmed]
  24. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Kamanaka, M., Yu, P., Yasui, T., Yoshida, K., Kawabe, T., Horii, T., Kishimoto, T., Kikutani, H. Immunity (1996) [Pubmed]
  25. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Franzoso, G., Carlson, L., Scharton-Kersten, T., Shores, E.W., Epstein, S., Grinberg, A., Tran, T., Shacter, E., Leonardi, A., Anver, M., Love, P., Sher, A., Siebenlist, U. Immunity (1997) [Pubmed]
  26. Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism. Zheng, L.M., Ojcius, D.M., Garaud, F., Roth, C., Maxwell, E., Li, Z., Rong, H., Chen, J., Wang, X.Y., Catino, J.J., King, I. J. Exp. Med. (1996) [Pubmed]
  27. Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. Constant, S., Pfeiffer, C., Woodard, A., Pasqualini, T., Bottomly, K. J. Exp. Med. (1995) [Pubmed]
  28. Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor. O'Reilly, R.J., Dupont, B., Pahwa, S., Grimes, E., Smithwick, E.M., Pahwa, R., Schwartz, S., Hansen, J.A., Siegal, F.P., Sorell, M., Svejgaard, A., Jersild, C., Thomsen, M., Platz, P., L'Esperance, P., Good, R.A. N. Engl. J. Med. (1977) [Pubmed]
  29. Efficacy of low-dose methotrexate in rheumatoid arthritis. Weinblatt, M.E., Coblyn, J.S., Fox, D.A., Fraser, P.A., Holdsworth, D.E., Glass, D.N., Trentham, D.E. N. Engl. J. Med. (1985) [Pubmed]
  30. Prostaglandin modulation of development of cell-mediated immunity in culture. Leung, K.H., Mihich, E. Nature (1980) [Pubmed]
  31. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. Meydani, S.N., Meydani, M., Blumberg, J.B., Leka, L.S., Siber, G., Loszewski, R., Thompson, C., Pedrosa, M.C., Diamond, R.D., Stollar, B.D. JAMA (1997) [Pubmed]
  32. Health effects of long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Hoffman, R.E., Stehr-Green, P.A., Webb, K.B., Evans, R.G., Knutsen, A.P., Schramm, W.F., Staake, J.L., Gibson, B.B., Steinberg, K.K. JAMA (1986) [Pubmed]
  33. Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. Hernandez, P.A., Gorlin, R.J., Lukens, J.N., Taniuchi, S., Bohinjec, J., Francois, F., Klotman, M.E., Diaz, G.A. Nat. Genet. (2003) [Pubmed]
  34. Altered immune responses in interleukin 10 transgenic mice. Hagenbaugh, A., Sharma, S., Dubinett, S.M., Wei, S.H., Aranda, R., Cheroutre, H., Fowell, D.J., Binder, S., Tsao, B., Locksley, R.M., Moore, K.W., Kronenberg, M. J. Exp. Med. (1997) [Pubmed]
  35. Molecular regulation of human interleukin 2 and T-cell function by interleukin 4. Schwarz, E.M., Salgame, P., Bloom, B.R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  36. Decreased interleukin-15 from activated cord versus adult peripheral blood mononuclear cells and the effect of interleukin-15 in upregulating antitumor immune activity and cytokine production in cord blood. Qian, J.X., Lee, S.M., Suen, Y., Knoppel, E., van de Ven, C., Cairo, M.S. Blood (1997) [Pubmed]
  37. Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis. Remoli, M.E., Giacomini, E., Lutfalla, G., Dondi, E., Orefici, G., Battistini, A., Uzé, G., Pellegrini, S., Coccia, E.M. J. Immunol. (2002) [Pubmed]
  38. Endogenous cell-mediated immunity, blood transfusion, and outcome of renal transplantation. Watson, M.A., Briggs, J.D., Diamandopoulos, A.A., Hamilton, D.N., Dick, H.M. Lancet (1979) [Pubmed]
  39. Improvement of cellular immunity and IgA production in immunodeficient children after treatment with synthetic serum thymic factor (FTS). Bordigoni, P., Faure, G., Bene, M.C., Dardenne, M., Bach, J.F., Duheille, J., Olive, D. Lancet (1982) [Pubmed]
  40. Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene. Burch, W.M., Snyderman, R. Ann. Intern. Med. (1982) [Pubmed]
  41. Suppression of secondary cellular immunity to a tumor allograft by cyclophosphamide and 1,3-bis(2-chloroethyl)-1-nitrosourea. Einstein, A.B., Fass, L., Fefer, A. Cancer Res. (1975) [Pubmed]
  42. Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms. Jankovic, D., Wynn, T.A., Kullberg, M.C., Hieny, S., Caspar, P., James, S., Cheever, A.W., Sher, A. J. Immunol. (1999) [Pubmed]
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