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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Solved and unsolved headache problems.

Two unusual cases of vascular headache, one caused by jugular venous compression from a goiter and one triggered by flushing associated with a CGRP-producing renal tumour, are reported. Their histories are compared with those experiencing other headaches of vascular origin. Two patients with a primary neural irritative lesion, one with a sphenoid sinus carcinoma and one with Tolosa-Hunt syndrome, presented with headaches resembling migraine. These case-histories are used to illustrate the interaction of nervous system and vascular system in the production of headache which has implications for the pathophysiology of migraine and cluster headache.[1]


  1. Solved and unsolved headache problems. Lance, J.W. Headache. (1991) [Pubmed]
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