The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Goiter


Psychiatry related information on Goiter


High impact information on Goiter

  • Efficacy was assessed by evaluating goiter size and measuring urinary iodine and serum thyroid hormone concentrations for 12 months [9].
  • Among the 21 patients studied serially while receiving levothyroxine, thyrotropin-blocking antibodies disappeared in 15 (group 1), 7 of whom had goiter initially, and persisted in 6 (group 2), none of whom had goiter initially [10].
  • Characteristically these patients exhibit hereditary congenital goiter with relatively low Tg levels that do not increase after stimulation with bovine TSH [11].
  • Congenital goiter with defective iodide transport [12].
  • Thyroglobulin and calcitonin in patients with nontoxic goiter [13].

Chemical compound and disease context of Goiter


Biological context of Goiter

  • Since few hypothyroid patients had autoimmunity or goiter, lithium may affect the thyroid gland directly [17].
  • We identified a homozygous missense mutation of A-->C at nucleotide +1060 in NIS complementary DNA in a male patient who was born from consanguineous marriage, had a huge goiter, and lacked the ability to accumulate iodide but was essentially euthyroid [19].
  • The data support the possibility that the TG accumulated in the follicular lumen of nontoxic goiters together with relative iodine deficiency contributes to increased MHC expression in thyroid cells in vivo and that increased MHC gene expression contributes to the ability of thyroid antigens to trigger an autoimmune reaction [20].
  • We report herein the study of two siblings (DESM and DSM) with hypothyroidism, goiter, and positive perchlorate discharge tests (50% and 70%) in a family (M) with no history of consanguinity [21].
  • The point mutation is, thus, removed from a portion of the transcripts by the preferential accumulation in the goiter of a 171-nt-deleted Tg mRNA [22].

Anatomical context of Goiter


Gene context of Goiter

  • The congenital goiter mutation is linked to the thyroglobulin gene in the mouse [28].
  • Here we report that the mRNA expression of PlGF, VEGF and their receptors is markedly enhanced in biopsies of goiters resected from Graves's patients [29].
  • Linkage of familial euthyroid goiter to the multinodular goiter-1 locus and exclusion of the candidate genes thyroglobulin, thyroperoxidase, and Na+/I- symporter [30].
  • By contrast, only three of five multinodular goiter samples were positive for IL-1 alpha mRNA; of these, two were also positive for IL-6, and 1 was positive for IL-8 mRNA [31].
  • Levels of fibroblast growth factor 2 (FGF-2) and its receptor, FGFR1, are elevated in goiter, but whether this is a direct effect of TSH is unknown [32].

Analytical, diagnostic and therapeutic context of Goiter


  1. Iodide-induced hypothyroidism: a potential hazard during perinatal life. Theodoropoulos, T., Braverman, L.E., Vagenakis, A.G. Science (1979) [Pubmed]
  2. Vaginal absorption of povidone-iodine. Vorherr, H., Vorherr, U.F., Mehta, P., Ulrich, J.A., Messer, R.H. JAMA (1980) [Pubmed]
  3. Reaccumulation of thyroglobulin and colloid in rat and mouse thyroid follicles during intense thyrotropin stimulation. A clue to the pathogenesis of colloid goiters. Gerber, H., Studer, H., Conti, A., Engler, H., Kohler, H., Haeberli, A. J. Clin. Invest. (1981) [Pubmed]
  4. High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Xu, X., Quiros, R.M., Gattuso, P., Ain, K.B., Prinz, R.A. Cancer Res. (2003) [Pubmed]
  5. Expression of ras oncogene p21 antigen in normal and proliferative thyroid tissues. Johnson, T.L., Lloyd, R.V., Thor, A. Am. J. Pathol. (1987) [Pubmed]
  6. Pharmacologic management of acute mania in pregnancy. Sitland-Marken, P.A., Rickman, L.A., Wells, B.G., Mabie, W.C. Journal of clinical psychopharmacology. (1989) [Pubmed]
  7. Adverse effects of poor micronutrient status during childhood and adolescence. Kapil, U., Bhavna, A. Nutr. Rev. (2002) [Pubmed]
  8. Dominantly inherited syndrome of microcephaly and cleft palate. Halal, F. Am. J. Med. Genet. (1983) [Pubmed]
  9. Efficacy of low oral doses of iodized oil in the control of iodine deficiency in Zaire. Tonglet, R., Bourdoux, P., Minga, T., Ermans, A.M. N. Engl. J. Med. (1992) [Pubmed]
  10. Disappearance of thyrotropin-blocking antibodies and spontaneous recovery from hypothyroidism in autoimmune thyroiditis. Takasu, N., Yamada, T., Takasu, M., Komiya, I., Nagasawa, Y., Asawa, T., Shinoda, T., Aizawa, T., Koizumi, Y. N. Engl. J. Med. (1992) [Pubmed]
  11. Defective thyroglobulin synthesis and secretion causing goiter and hypothyroidism. Medeiros-Neto, G., Targovnik, H.M., Vassart, G. Endocr. Rev. (1993) [Pubmed]
  12. Congenital goiter with defective iodide transport. Wolff, J. Endocr. Rev. (1983) [Pubmed]
  13. Thyroglobulin and calcitonin in patients with nontoxic goiter. Levine, G.A., Hershman, J.M., Van Herle, A.J., Deftos, L.J. JAMA (1978) [Pubmed]
  14. Tumorigenic effect of 3-amino-1H-1,2,4-triazole on rat thyroid. Tsuda, H., Hananouchi, M., Tatematsu, M., Hirose, M., Hirao, K. J. Natl. Cancer Inst. (1976) [Pubmed]
  15. The epizootiology and pathogenesis of thyroid hyperplasia in coho salmon (Oncorhynchus kisutch) in Lake Ontario. Sonstegard, R., Leatherland, J.F. Cancer Res. (1976) [Pubmed]
  16. Goiter formation following prostaglandin administration in rats. Lupulescu, A. Am. J. Pathol. (1976) [Pubmed]
  17. Thyroid function and ultrasonically determined thyroid size in patients receiving long-term lithium treatment. Perrild, H., Hegedüs, L., Baastrup, P.C., Kayser, L., Kastberg, S. The American journal of psychiatry. (1990) [Pubmed]
  18. Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis. Kaplan, J., Ish-Shalom, S. Am. J. Med. (1991) [Pubmed]
  19. A homozygous missense mutation of the sodium/iodide symporter gene causing iodide transport defect. Matsuda, A., Kosugi, S. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  20. Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. Schuppert, F., Ehrenthal, D., Frilling, A., Suzuki, K., Napolitano, G., Kohn, L.D. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  21. Goiter and hypothyroidism in two siblings due to impaired Ca(+2)/NAD(P)H-dependent H(2)O(2)-generating activity. Figueiredo, M.D., Cardoso, L.C., Ferreira, A.C., Campos, D.V., da Cruz Domingos, M., Corbo, R., Nasciutti, L.E., Vaisman, M., Carvalho, D.P. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  22. A nonsense mutation causes human hereditary congenital goiter with preferential production of a 171-nucleotide-deleted thyroglobulin ribonucleic acid messenger. Targovnik, H.M., Medeiros-Neto, G., Varela, V., Cochaux, P., Wajchenberg, B.L., Vassart, G. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  23. Congenital hypothyroid goiter with deficient thyroglobulin. Identification of an endoplasmic reticulum storage disease with induction of molecular chaperones. Medeiros-Neto, G., Kim, P.S., Yoo, S.E., Vono, J., Targovnik, H.M., Camargo, R., Hossain, S.A., Arvan, P. J. Clin. Invest. (1996) [Pubmed]
  24. Levothyroxine therapy in patients with thyroid disease. Mandel, S.J., Brent, G.A., Larsen, P.R. Ann. Intern. Med. (1993) [Pubmed]
  25. Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients. Alicigüzel, Y., Ozdem, S.N., Ozdem, S.S., Karayalçin, U., Siedlak, S.L., Perry, G., Smith, M.A. Free Radic. Biol. Med. (2001) [Pubmed]
  26. Intrauterine diagnosis and treatment of fetal goitrous hypothyroidism. Perelman, A.H., Johnson, R.L., Clemons, R.D., Finberg, H.J., Clewell, W.H., Trujillo, L. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  27. Estrogen promotes growth of human thyroid tumor cells by different molecular mechanisms. Manole, D., Schildknecht, B., Gosnell, B., Adams, E., Derwahl, M. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  28. The congenital goiter mutation is linked to the thyroglobulin gene in the mouse. Taylor, B.A., Rowe, L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  29. Upregulation of the angiogenic factors PlGF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization. Viglietto, G., Romano, A., Manzo, G., Chiappetta, G., Paoletti, I., Califano, D., Galati, M.G., Mauriello, V., Bruni, P., Lago, C.T., Fusco, A., Persico, M.G. Oncogene (1997) [Pubmed]
  30. Linkage of familial euthyroid goiter to the multinodular goiter-1 locus and exclusion of the candidate genes thyroglobulin, thyroperoxidase, and Na+/I- symporter. Neumann, S., Willgerodt, H., Ackermann, F., Reske, A., Jung, M., Reis, A., Paschke, R. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  31. Analysis of cytokine gene expression in Graves' disease and multinodular goiter. Watson, P.F., Pickerill, A.P., Davies, R., Weetman, A.P. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  32. Adenovirus-mediated expression of dominant negative fibroblast growth factor (FGF) receptor 1 in thyroid cells blocks FGF effects and reduces goitrogenesis in mice. Davies, E.L., Ramsden, J.D., Cocks, H., Searle, P.F., Watkinson, J.C., Ueno, H., Logan, A., Franklyn, J.A., Mautner, V., Eggo, M.C. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  33. A 3' splice site mutation in the thyroglobulin gene responsible for congenital goiter with hypothyroidism. Ieiri, T., Cochaux, P., Targovnik, H.M., Suzuki, M., Shimoda, S., Perret, J., Vassart, G. J. Clin. Invest. (1991) [Pubmed]
  34. Skeletal integrity in men chronically treated with suppressive doses of L-thyroxine. Marcocci, C., Golia, F., Vignali, E., Pinchera, A. J. Bone Miner. Res. (1997) [Pubmed]
  35. Immunohistochemical detection and localization of a 72-kilodalton heat shock protein in autoimmune thyroid disease. Heufelder, A.E., Goellner, J.R., Wenzel, B.E., Bahn, R.S. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  36. Fibroblast growth factors 1 and 2 and fibroblast growth factor receptor 1 are elevated in thyroid hyperplasia. Thompson, S.D., Franklyn, J.A., Watkinson, J.C., Verhaeg, J.M., Sheppard, M.C., Eggo, M.C. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  37. Serum thyroglobulin changes in patients with Graves' disease treated with long term antithyroid drug therapy. Kawamura, S., Kishino, B., Tajima, K., Mashita, K., Tarui, S. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
WikiGenes - Universities