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MeSH Review

Vascular Headaches

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Disease relevance of Vascular Headaches

  • Based on this experience, we would caution against the use of unopposed beta-blockade in this setting and suggest that the role of prazosin in the initial management of postendarterectomy hypertension and vascular headache be explored [1].
  • Increases in LCBF were significantly asymmetric among migraine and cluster patients and provoked typical unilateral vascular headaches which responded to sumatriptan [2].
  • Two unusual cases of vascular headache, one caused by jugular venous compression from a goiter and one triggered by flushing associated with a CGRP-producing renal tumour, are reported [3].

Psychiatry related information on Vascular Headaches

  • It is recommended that physicians treating epilepsy, vascular headaches, or mood disorders with divalproate consider the diagnosis of PTC when their patients complain of new onset of headaches or an increase in frequency or severity of existing headaches--especially those associated with a visual disturbance--to prevent permanent visual loss [4].

High impact information on Vascular Headaches

  • Further impetus may come from ongoing studies of H3 histamine receptors, which indicate that H3 agonists offer promise as prophylactic agents for people who suffer from vascular headaches [5].
  • We treated 64 emergency room patients with a primary vascular headache with dihydroergotamine (DHE), meperidine, or butorphanol [6].
  • The variable duration and intensity of the headache in different patients can be explained by the pressor and cranial vasoconstrictor effects of the secreted amines, which respectively enhance and diminish vascular headache [7].
  • This study addresses possible interactions of the vasodilators nitric oxide (NO), calcitonin gene-related peptide (CGRP) and prostaglandins, which may be implicated in the generation of vascular headaches [8].
  • Cocaine-related vascular headaches [9].

Chemical compound and disease context of Vascular Headaches


Biological context of Vascular Headaches

  • Localized reduction in the expected blood flow surge after CO2 inhalation, most often noted posteriorly, was seen in 8 of the 13 vascular headaches, but in none of the musculoskeletal headache group [13].

Anatomical context of Vascular Headaches


Gene context of Vascular Headaches

  • Because 5-HT1-like agonists, which are useful for treating migraine and related headaches, share similar inhibitory properties in this in vivo model, the significance of prejunctional alpha 2, histamine H3 and somatostatin receptors to treatment of vascular headaches is suggested [15].
  • The MS patients had tension headaches or vascular headaches of the migraine type; there was no distinctive "MS headache." Seven of these patients had headaches with their first MS symptoms, but in only one did headaches recur with disease activity [16].


  1. Hypertension, vascular headaches, and seizures after carotid endarterectomy. Case report and therapeutic considerations. Dolan, J.G., Mushlin, A.I. Arch. Intern. Med. (1984) [Pubmed]
  2. Acetazolamide testing of cerebral vasodilator capacity provokes "vascular" but not tension headaches. Shirai, T., Meyer, J.S., Akiyama, H., Mortel, K.F., Wills, P.M. Headache. (1996) [Pubmed]
  3. Solved and unsolved headache problems. Lance, J.W. Headache. (1991) [Pubmed]
  4. Drug-induced pseudotumor cerebri. Uddin, A.B. Clinical neuropharmacology. (2003) [Pubmed]
  5. The role of antihistamine therapy in vascular headaches. Mansfield, L.E. J. Allergy Clin. Immunol. (1990) [Pubmed]
  6. Comparison of single-dose meperidine, butorphanol, and dihydroergotamine in the treatment of vascular headache. Belgrade, M.J., Ling, L.J., Schleevogt, M.B., Ettinger, M.G., Ruiz, E. Neurology (1989) [Pubmed]
  7. Symptoms of pheochromocytoma, with particular reference to headache, correlated with catecholamine production. Lance, J.W., Hinterberger, H. Arch. Neurol. (1976) [Pubmed]
  8. Increase in meningeal blood flow by nitric oxide--interaction with calcitonin gene-related peptide receptor and prostaglandin synthesis inhibition. Strecker, T., Dux, M., Messlinger, K. Cephalalgia : an international journal of headache. (2002) [Pubmed]
  9. Cocaine-related vascular headaches. Dhuna, A., Pascual-Leone, A., Belgrade, M. J. Neurol. Neurosurg. Psychiatr. (1991) [Pubmed]
  10. 5-Hydroxytryptamine receptor agonists for the abortive treatment of vascular headaches block mast cell, endothelial and platelet activation within the rat dura mater after trigeminal stimulation. Buzzi, M.G., Dimitriadou, V., Theoharides, T.C., Moskowitz, M.A. Brain Res. (1992) [Pubmed]
  11. Immunohistochemical localization of endothelial nitric oxide synthase in vessels of the dura mater of the Sprague-Dawley rat. Nemade, R.V., Lewis, A.I., Zuccarello, M., Keller, J.T. Neurosci. Lett. (1995) [Pubmed]
  12. The thermographically observed effects of hyperoxia on vascular headache patients and non-headache individuals. Swerdlow, B., Dieter, J.N. Headache. (1987) [Pubmed]
  13. Regional cerebral blood flow in childhood headache. Roach, E.S., Stump, D.A. Headache. (1989) [Pubmed]
  14. Rationale for the use of 5-HT1-like agonists in the treatment of migraine. Feniuk, W., Humphrey, P.P., Perren, M.J., Connor, H.E., Whalley, E.T. J. Neurol. (1991) [Pubmed]
  15. UK-14,304, R(-)-alpha-methyl-histamine and SMS 201-995 block plasma protein leakage within dura mater by prejunctional mechanisms. Matsubara, T., Moskowitz, M.A., Huang, Z. Eur. J. Pharmacol. (1992) [Pubmed]
  16. Headaches and multiple sclerosis: a clinical study and review of the literature. Rolak, L.A., Brown, S. J. Neurol. (1990) [Pubmed]
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