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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative.

The bioequivalence of thiamin in 2 therapeutically used preparations was tested in 10 healthy young men. Thiamin was orally administered either as lipophilic benfotiamine or as water-soluble thiamin mononitrate. Biokinetic data, measured as area under the curve and maximal concentration in plasma and hemolysate after ingestion, demonstrated a significantly improved bioavailability from the lipophilic derivative despite an ingested dose of only 40% as compared with the water-soluble salt. A superior cellular efficacy of benfotiamine was also concluded from the short-term stimulation of the thiamin-dependent transketolase activity in erythrocytes.[1]

References

  1. Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. Bitsch, R., Wolf, M., Möller, J., Heuzeroth, L., Grüneklee, D. Ann. Nutr. Metab. (1991) [Pubmed]
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