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Chemical Compound Review

Betivina     [(Z)-4-[(4-amino-2-methyl- pyrimidin-5...

Synonyms: Biotamin, Tabiomyl, milgamma, Bietamine, Neurostop, ...
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Disease relevance of S-Benzoylthiamine monophosphate


High impact information on S-Benzoylthiamine monophosphate


Chemical compound and disease context of S-Benzoylthiamine monophosphate


Biological context of S-Benzoylthiamine monophosphate


Anatomical context of S-Benzoylthiamine monophosphate

  • The aim of this study was to evaluate whether benfotiamine is of benefit in reparative neovascularisation using a type I diabetes model of hindlimb ischaemia [5].

Associations of S-Benzoylthiamine monophosphate with other chemical compounds


Gene context of S-Benzoylthiamine monophosphate

  • In addition, benfotiamine prevented the vascular accumulation of advanced glycation end products and the induction of pro-apoptotic caspase-3, while restoring proper expression of Nos3 and Akt in ischaemic muscles [5].
  • We also investigated the involvement of protein kinase B (PKB)/Akt in the therapeutic effects of benfotiamine [5].
  • RESULTS: Diabetic muscles showed reduced transketolase activity, which was corrected by benfotiamine [5].
  • The effects of HAGE on both FMD and reactive hyperemia were completely prevented by benfotiamine [9].
  • Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha [12].

Analytical, diagnostic and therapeutic context of S-Benzoylthiamine monophosphate


  1. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Hammes, H.P., Du, X., Edelstein, D., Taguchi, T., Matsumura, T., Ju, Q., Lin, J., Bierhaus, A., Nawroth, P., Hannak, D., Neumaier, M., Bergfeld, R., Giardino, I., Brownlee, M. Nat. Med. (2003) [Pubmed]
  2. Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling. Marchetti, V., Menghini, R., Rizza, S., Vivanti, A., Feccia, T., Lauro, D., Fukamizu, A., Lauro, R., Federici, M. Diabetes (2006) [Pubmed]
  3. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Babaei-Jadidi, R., Karachalias, N., Ahmed, N., Battah, S., Thornalley, P.J. Diabetes (2003) [Pubmed]
  4. Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. Berrone, E., Beltramo, E., Solimine, C., Ape, A.U., Porta, M. J. Biol. Chem. (2006) [Pubmed]
  5. Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis. Gadau, S., Emanueli, C., Van Linthout, S., Graiani, G., Todaro, M., Meloni, M., Campesi, I., Invernici, G., Spillmann, F., Ward, K., Madeddu, P. Diabetologia (2006) [Pubmed]
  6. High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine. Frank, T., Bitsch, R., Maiwald, J., Stein, G. Eur. J. Clin. Pharmacol. (2000) [Pubmed]
  7. Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study). Haupt, E., Ledermann, H., Köpcke, W. International journal of clinical pharmacology and therapeutics. (2005) [Pubmed]
  8. Crystal Structures of the Thi-Box Riboswitch Bound to Thiamine Pyrophosphate Analogs Reveal Adaptive RNA-Small Molecule Recognition. Edwards, T.E., Ferré-D'Amaré, A.R. Structure (2006) [Pubmed]
  9. Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. Stirban, A., Negrean, M., Stratmann, B., Gawlowski, T., Horstmann, T., Götting, C., Kleesiek, K., Mueller-Roesel, M., Koschinsky, T., Uribarri, J., Vlassara, H., Tschoepe, D. Diabetes Care (2006) [Pubmed]
  10. Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. Bitsch, R., Wolf, M., Möller, J., Heuzeroth, L., Grüneklee, D. Ann. Nutr. Metab. (1991) [Pubmed]
  11. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Loew, D. International journal of clinical pharmacology and therapeutics. (1996) [Pubmed]
  12. Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha. Wu, S., Ren, J. Neurosci. Lett. (2006) [Pubmed]
  13. Benfotiamine relieves inflammatory and neuropathic pain in rats. Sánchez-Ramírez, G.M., Caram-Salas, N.L., Rocha-González, H.I., Vidal-Cantú, G.C., Medina-Santillán, R., Reyes-García, G., Granados-Soto, V. Eur. J. Pharmacol. (2006) [Pubmed]
  14. Alteration of thiamine pharmacokinetics by end-stage renal disease (ESRD). Frank, T., Bitsch, R., Maiwald, J., Stein, G. International journal of clinical pharmacology and therapeutics. (1999) [Pubmed]
  15. Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study (BAP I Study). Woelk, H., Lehrl, S., Bitsch, R., Köpcke, W. Alcohol Alcohol. (1998) [Pubmed]
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