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MeSH Review

Therapeutic Equivalency

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Disease relevance of Therapeutic Equivalency


Psychiatry related information on Therapeutic Equivalency

  • Two crossover bioequivalence trials of an enantioselectively enterohepatic recycled drug, carprofen, were conducted in dogs with the same racemic oral formulation to determine: (i) the influence of feeding patterns, and (ii) the effect of the analytical method (enantioselective vs non-enantioselective) on the statistical power of the trials [6].

High impact information on Therapeutic Equivalency


Chemical compound and disease context of Therapeutic Equivalency

  • Therefore, a bioequivalence study using a randomized crossover design (reference = without glycine, test = with glycine) in 12 healthy male volunteers (age 22 - 38 (median 26) years, body weight 64 - 83 (median 75) kg) was performed [11].
  • Dose proportionality of stavudine in HIV seropositive asymptomatic subjects: application to bioequivalence assessment of various capsule formulations [12].
  • A randomized, two-way, crossover, bioequivalence study was conducted in 26 fasting, healthy, male volunteers to compare two brands of citalopram 40 mg tablets, Citol (Abdi Ibrahim Ilaç San. ve Tic A.S., Istanbul, Turkey) as a test and Cipramil (H. Lundbeck A/S, Copenhagen, Denmark) as a reference product [13].
  • Comparative open, randomized, cross-over bioequivalence study of two intravenous dexrazoxane formulations (Cardioxane and ICRF-187) in patients with advanced breast cancer, treated with 5-fluorouracil-doxorubicin-cyclophosphamide (FDC) [14].

Biological context of Therapeutic Equivalency


Anatomical context of Therapeutic Equivalency


Associations of Therapeutic Equivalency with chemical compounds


Gene context of Therapeutic Equivalency


Analytical, diagnostic and therapeutic context of Therapeutic Equivalency


  1. Ciclopirox olamine lotion 1%: bioequivalence to ciclopirox olamine cream 1% and clinical efficacy in tinea pedis. Aly, R., Maibach, H.I., Bagatell, F.K., Dittmar, W., Hänel, H., Falanga, V., Leyden, J.J., Roth, H.L., Stoughton, R.B., Willis, I. Clinical therapeutics. (1989) [Pubmed]
  2. Comparison of the efficacy and bioequivalence of two oral formulations of tiludronate in the treatment of Paget's disease of bone. Morales-Piga, A., Del Pino, J., Rapado, A., Diaz-Curiel, M., Pallares, M., Gonzalez-Macias, J. Clinical therapeutics. (1997) [Pubmed]
  3. Comparative bioavailability of various thiamine derivatives after oral administration. Greb, A., Bitsch, R. International journal of clinical pharmacology and therapeutics. (1998) [Pubmed]
  4. Bioequivalence study of nicardipine solution versus nicardipine tablets. Mignini, F., Bisbocci, D., Paglieri, C., Streccioni, V., Veglio, F., Amenta, F. Clin. Exp. Hypertens. (2004) [Pubmed]
  5. Part II: clinical efficacy and tolerability of zolmitriptan orally disintegrating tablet in the acute treatment of migraine. Loder, E.W., Dowson, A.J., Spierings, E.L. Current medical research and opinion. (2005) [Pubmed]
  6. Influence of feeding and analytical method on the bioequivalence of a racemic drug undergoing enantioselective enterohepatic recycling. Priymenko, N.M., Koritz, G.D., Ferre, J.P., Laroute, V.M., Toutain, P.L. Journal of pharmaceutical sciences. (2004) [Pubmed]
  7. Bioequivalence of levothyroxine preparations: industry sponsorship and academic freedom. Eckert, C.H. JAMA (1997) [Pubmed]
  8. Saquinavir 500 mg film-coated tablets demonstrate bioequivalence to saquinavir 200 mg hard capsules when boosted with twice-daily ritonavir in healthy volunteers. Bittner, B., Riek, M., Holmes, B., Grange, S. Antivir. Ther. (Lond.) (2005) [Pubmed]
  9. Tamoxifen dosage and bioequivalence: a correction. Mondzac, A.M. J. Clin. Oncol. (1994) [Pubmed]
  10. Lack of an effect of atazanavir on steady-state pharmacokinetics of methadone in patients chronically treated for opiate addiction. Friedland, G., Andrews, L., Schreibman, T., Agarwala, S., Daley, L., Child, M., Shi, J., Wang, Y., O'Mara, E. AIDS (2005) [Pubmed]
  11. Lack of influence of glycine on the single dose pharmacokinetics of acetylsalicylic acid in man. Schurer, M., Bias-Imhoff, U., Schulz, H.U., Schwantes, U., Riechers, A.M. International journal of clinical pharmacology and therapeutics. (1996) [Pubmed]
  12. Dose proportionality of stavudine in HIV seropositive asymptomatic subjects: application to bioequivalence assessment of various capsule formulations. Kaul, S., Mummaneni, V., Barbhaiya, R.H. Biopharmaceutics & drug disposition. (1995) [Pubmed]
  13. Bioequivalence of two brands of citalopram 40 mg tablets after single oral administration to healthy volunteers. Mendoza, L., Hajdúch, M., Kekulová, H., Svobodová, X., Mihál, V., Svoboda, M. Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia. (2005) [Pubmed]
  14. Comparative open, randomized, cross-over bioequivalence study of two intravenous dexrazoxane formulations (Cardioxane and ICRF-187) in patients with advanced breast cancer, treated with 5-fluorouracil-doxorubicin-cyclophosphamide (FDC). Rosing, H., ten Bokkel Huinink, W.W., van Gijn, R., Rombouts, R.F., Bult, A., Beijnen, J.H. European journal of drug metabolism and pharmacokinetics. (1999) [Pubmed]
  15. Quinidine interaction with nifedipine and felodipine: pharmacokinetic and pharmacodynamic evaluation. Bailey, D.G., Freeman, D.J., Melendez, L.J., Kreeft, J.H., Edgar, B., Carruthers, S.G. Clin. Pharmacol. Ther. (1993) [Pubmed]
  16. Subnanogram-concentration measurement of buprenorphine in human plasma by electron-capture capillary gas chromatography: application to pharmacokinetics of sublingual buprenorphine. Everhart, E.T., Cheung, P., Shwonek, P., Zabel, K., Tisdale, E.C., Jacob, P., Mendelson, J., Jones, R.T. Clin. Chem. (1997) [Pubmed]
  17. Feasibility of Biowaiver Extension to Biopharmaceutics Classification System Class III Drug Products : Cimetidine. Jantratid, E., Prakongpan, S., Amidon, G.L., Dressman, J.B. Clinical pharmacokinetics. (2006) [Pubmed]
  18. Bioequivalence of a new liquid formulation of ursodeoxycholic acid (Ursofalk suspension) and Ursofalk capsules measured by plasma pharmacokinetics and biliary enrichment. Setchell, K.D., Galzigna, L., O'Connell, N., Brunetti, G., Tauschel, H.D. Aliment. Pharmacol. Ther. (2005) [Pubmed]
  19. A randomized crossover study to determine bioequivalence of generic and brand name nevirapine, zidovudine, and lamivudine in HIV-negative women in India. Vezina, H.E., Henry, K., Ravindran, G.D., Kurpad, A.V., Raj, T.D., Fox, K., Weller, D., Brundage, R.C., Cavert, W., Balfour, H.H. J. Acquir. Immune Defic. Syndr. (2006) [Pubmed]
  20. Evaluation of the therapeutic efficacy of different levothyroxine preparations in the treatment of human thyroid disease. Klein, I., Danzi, S. Thyroid (2003) [Pubmed]
  21. Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide. Blume, C.D., Williams, R.L., Upton, R.A., Lin, E.T., Benet, L.Z. Am. J. Med. (1984) [Pubmed]
  22. Bioequivalence study of nabumetone: tablet versus suspension. Daigneault, E.A., Ferslew, K.E., Stanton, P. Am. J. Med. (1987) [Pubmed]
  23. A methacholine challenge dose-response study for development of a pharmacodynamic bioequivalence methodology for albuterol metered- dose inhalers. Creticos, P.S., Adams, W.P., Petty, B.G., Lewis, L.D., Singh, G.J., Khattignavong, A.P., Molzon, J.A., Martinez, M.N., Lietman, P.S., Williams, R.L. J. Allergy Clin. Immunol. (2002) [Pubmed]
  24. Development of in vivo bioequivalence methodology for dermatologic corticosteroids based on pharmacodynamic modeling. Singh, G.J., Adams, W.P., Lesko, L.J., Shah, V.P., Molzon, J.A., Williams, R.L., Pershing, L.K. Clin. Pharmacol. Ther. (1999) [Pubmed]
  25. Bioequivalence revisited: influence of age and sex on CYP enzymes. Bebia, Z., Buch, S.C., Wilson, J.W., Frye, R.F., Romkes, M., Cecchetti, A., Chaves-Gnecco, D., Branch, R.A. Clin. Pharmacol. Ther. (2004) [Pubmed]
  26. High-dose omeprazole: use of a multiple-dose study design to assess bioequivalence and accuracy of CYP2C19 phenotyping. Kovacs, P., Edwards, D.J., Lalka, D., Scheiwe, W.M., Stoeckel, K. Therapeutic drug monitoring. (1999) [Pubmed]
  27. Unaltered etanercept pharmacokinetics with concurrent methotrexate in patients with rheumatoid arthritis. Zhou, H., Mayer, P.R., Wajdula, J., Fatenejad, S. Journal of clinical pharmacology. (2004) [Pubmed]
  28. Simultaneous itraconazole bioequivalence assessment and CYP3A phenotyping in South American subjects. Estevez-Carrizo, F.E., Ruiz, S., Bellocq, B., Leal, C., Siri, M.T., del Campo, M.J. International journal of clinical pharmacology and therapeutics. (2005) [Pubmed]
  29. Bioequivalence of azathioprine products. Baker, D.E. Reviews in gastroenterological disorders. (2003) [Pubmed]
  30. The bioequivalence of telithromycin administered orally as crushed tablets versus tablets swallowed whole. Lippert, C., Gbenado, S., Qiu, C., Lavin, B., Kovacs, S.J. Journal of clinical pharmacology. (2005) [Pubmed]
  31. Reversed-phase high-performance liquid chromatography of ketorolac and its application to bioequivalence studies in human serum. Chaudhary, R.S., Gangwal, S.S., Jindal, K.C., Khanna, S. J. Chromatogr. (1993) [Pubmed]
  32. Assay of timolol in human plasma using gas chromatography with electron-capture detection. Sutton, B.M., Richardson, R.A. J. Chromatogr. (1992) [Pubmed]
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