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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Primary non-Hodgkin's lymphomas of the major salivary glands.

BACKGROUND: The clinical course of primary salivary gland lymphomas has received little attention. METHODS: We retrospectively assessed 20 patients with previously untreated non-Hodgkin's lymphomas (NHLs) and histologically confirmed as having parenchymal involvement of the salivary glands. The clinical presentation, therapy, and outcomes were compared between the 12 patients with mucosa-associated lymphoid tissue (MALT) lymphomas and the 8 patients with other NHLs. RESULTS: At diagnosis, the 12 patients with MALT lymphoma had a greater mean age and longer duration than did the 8 patients with other NHLs (P < 0.05). Eight of the 12 MALT lymphoma patients had recurrent episodes of salivary gland swelling and 5 had myoepithelial sialadenitis, Sjögren syndrome, or gastric MALT lymphoma; these were not observed in the 8 other NHL patients. Compared with the latter group, the MALT lymphoma group had significantly greater five-year relapse-free (37.5% vs. 91.7%, P < 0.05) and disease-free (35.0% vs. 90.9%, P < 0.05) survival rates. However, two MALT lymphoma patients with high-grade transformation had recurrences beyond the head and neck region. CONCLUSION: Understanding the distinct clinical presentation and course of primary salivary gland lymphomas may help guide the proper diagnosis and management of patients with these tumors.[1]


  1. Primary non-Hodgkin's lymphomas of the major salivary glands. Roh, J.L., Huh, J., Suh, C. J. Surg. Oncol (2008) [Pubmed]
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