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Disease relevance of Sialadenitis


High impact information on Sialadenitis

  • Oxyphenbutazone-induced sialadenitis [6].
  • The prevalence of anti-glutamic acid decarboxylase autoantibodies and of sialitis is not increased in proinsulin 2(-/-) mice [7].
  • CONCLUSION: Arthropathy in DBA/1 mice is under the control of an allelic combination of gene loci, one of which is common to the locus for sialadenitis in MRL/MpJ-lpr/lpr mice [8].
  • More than 19 chromosomal intervals (referred to as Idd regions) that contribute to diabetes susceptibility in the NOD mouse model have been identified, but only 2 chromosomal intervals (associated with Idd3 and Idd5) have been shown to control sialadenitis [9].
  • RESULTS: Following MCMV infection, B6-gld/gld mice developed an acute and chronic sialadenitis characterized by multiple foci of infiltrating T cells [4].

Chemical compound and disease context of Sialadenitis


Biological context of Sialadenitis


Anatomical context of Sialadenitis


Gene context of Sialadenitis

  • CONCLUSION: Chronic sialadenitis similar to that of SS developed in B6-gld/gld mice after MCMV infection [4].
  • In focal sialadenitis, some acinar cells showed staining with PCNA as well as with Klenow [21].
  • In the present study, the expression of CTGF, MMP-2, -3, -9, -13 and TIMP-3 was examined in chronic obstructive sialadenitis [22].
  • CONCLUSION: These results indicate that JNK and p38, but not ERK, function as downstream effector molecules of CD40 in salivary infiltrating MNCs in SS patients, and suggest that these molecules may be involved in the pathological process of chronic sialadenitis in SS [23].
  • Patients with positive rheumatoid factor (RF), antinuclear antibodies (ANA), or SSA or SSB antibodies had sialadenitis significantly more often than did patients with negative antibodies [5].

Analytical, diagnostic and therapeutic context of Sialadenitis


  1. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Kurobe, H., Liu, C., Ueno, T., Saito, F., Ohigashi, I., Seach, N., Arakaki, R., Hayashi, Y., Kitagawa, T., Lipp, M., Boyd, R.L., Takahama, Y. Immunity (2006) [Pubmed]
  2. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. Groom, J., Kalled, S.L., Cutler, A.H., Olson, C., Woodcock, S.A., Schneider, P., Tschopp, J., Cachero, T.G., Batten, M., Wheway, J., Mauri, D., Cavill, D., Gordon, T.P., Mackay, C.R., Mackay, F. J. Clin. Invest. (2002) [Pubmed]
  3. Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma. Ye, H., Liu, H., Attygalle, A., Wotherspoon, A.C., Nicholson, A.G., Charlotte, F., Leblond, V., Speight, P., Goodlad, J., Lavergne-Slove, A., Martin-Subero, J.I., Siebert, R., Dogan, A., Isaacson, P.G., Du, M.Q. Blood (2003) [Pubmed]
  4. Treatment of chronic sialadenitis in a murine model of Sjögren's syndrome by local fasL gene transfer. Fleck, M., Zhang, H.G., Kern, E.R., Hsu, H.C., Müller-Ladner, U., Mountz, J.D. Arthritis Rheum. (2001) [Pubmed]
  5. Focal sialadenitis in patients with ankylosing spondylitis and spondyloarthropathy: a comparison with patients with rheumatoid arthritis or mixed connective tissue disease. Helenius, L.M., Hietanen, J.H., Helenius, I., Kautiainen, H., Piirainen, H., Paimela, L., Lappalainen, M., Suuronen, R., Lindqvist, C., Leirisalo-Repo, M. Ann. Rheum. Dis. (2001) [Pubmed]
  6. Oxyphenbutazone-induced sialadenitis. Chen, J.H., Ottolenghi, P., Distenfeld, A. JAMA (1977) [Pubmed]
  7. Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. Thébault-Baumont, K., Dubois-Laforgue, D., Krief, P., Briand, J.P., Halbout, P., Vallon-Geoffroy, K., Morin, J., Laloux, V., Lehuen, A., Carel, J.C., Jami, J., Muller, S., Boitard, C. J. Clin. Invest. (2003) [Pubmed]
  8. Accelerating effect of an MRL gene locus on the severity and onset of arthropathy in DBA/1 mice. Oishi, H., Miyazaki, T., Mizuki, S., Kamogawa, J., Lu, L.M., Tsubaki, T., Arita, N., Ono, M., Yamamoto, H., Nose, M. Arthritis Rheum. (2005) [Pubmed]
  9. Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background. Cha, S., Nagashima, H., Brown, V.B., Peck, A.B., Humphreys-Beher, M.G. Arthritis Rheum. (2002) [Pubmed]
  10. Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: additive and hierarchical properties of polygenic inheritance. Nishihara, M., Terada, M., Kamogawa, J., Ohashi, Y., Mori, S., Nakatsuru, S., Nakamura, Y., Nose, M. Arthritis Rheum. (1999) [Pubmed]
  11. Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. Quartey-Papafio, R., Lund, T., Chandler, P., Picard, J., Ozegbe, P., Day, S., Hutchings, P.R., O'Reilly, L., Kioussis, D., Simpson, E. J. Immunol. (1995) [Pubmed]
  12. Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2(s) congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes. Greve, B., Reddy, J., Waldner, H.P., Sobel, R.A., Kuchroo, V.K. Eur. J. Immunol. (2004) [Pubmed]
  13. Demonstration of unilateral sialadenitis on postradiotherapy gallium-67-citrate imaging. Oates, E., Touliopoulos, P., Wazer, D.E. J. Nucl. Med. (1993) [Pubmed]
  14. Localization of gallium-67 citrate in salivary glands following radiation therapy. Lentle, B.C., Jackson, F.I., Mcgowan, D.G. Am. J. Surg. (1976) [Pubmed]
  15. Analysis of immunoglobulin heavy chain gene rearrangement in myoepithelial sialadenitis by polymerase chain reaction. Hsi, E.D., Siddiqui, J., Schnitzer, B., Alkan, S., Ross, C.W. Am. J. Clin. Pathol. (1996) [Pubmed]
  16. Short-term administration of selected anti-T-cell receptor V beta chain specific MoAb reduces sialadenitis in MRL/lpr mice. Skarstein, K., Holmdahl, R., Johannessen, A.C., Goldschmidt, T., Jonsson, R. Scand. J. Immunol. (1995) [Pubmed]
  17. Expression of TNF-related apoptosis inducing ligand (TRAIL) on infiltrating cells and of TRAIL receptors on salivary glands in patients with Sjögren's syndrome. Matsumura, R., Umemiya, K., Kagami, M., Tomioka, H., Tanabe, E., Sugiyama, T., Sueishi, M., Kayagaki, N., Yagita, H., Okumura, K. Clinical and experimental rheumatology. (2002) [Pubmed]
  18. Development of allergic sialadenitis in mice immunized with mumps virus-infected submandibular salivary gland. Hayashi, Y., Yura, Y., Yoshida, H., Yanagawa, T., Sato, M. Am. J. Pathol. (1986) [Pubmed]
  19. Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. O'Sullivan, F.X., Vogelweid, C.M., Besch-Williford, C.L., Walker, S.E. J. Autoimmun. (1995) [Pubmed]
  20. Fine needle aspiration biopsy of the salivary glands. A five-year experience with emphasis on diagnostic pitfalls. Cajulis, R.S., Gokaslan, S.T., Yu, G.H., Frias-Hidvegi, D. Acta Cytol. (1997) [Pubmed]
  21. Ku protein and DNA strand breaks in lip glands of normal and primary Sjögren's syndrome subjects: lack of correlation with apoptosis. Larsson A, n.u.l.l., Henriksson, G., Manthorpe, R., Sallmyr, A., Bredberg, A. Scand. J. Immunol. (2001) [Pubmed]
  22. Extracellular matrix molecules in chronic obstructive sialadenitis: an immunocytochemical and Western blot investigation. Teymoortash, A., Mandic, R., Schrader, C., Werner, J.A. Journal of oral science. (2004) [Pubmed]
  23. Expression of mitogen activated protein kinases in labial salivary glands of patients with Sjögren's syndrome. Nakamura, H., Kawakami, A., Yamasaki, S., Kawabe, Y., Nakamura, T., Eguchi, K. Ann. Rheum. Dis. (1999) [Pubmed]
  24. Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice. Gerling, I.C., Serreze, D.V., Christianson, S.W., Leiter, E.H. Diabetes (1992) [Pubmed]
  25. Autoantibodies to La/SSB in patients with primary Sjögren's syndrome (pSS) are associated with upregulation of La/SSB mRNA in minor salivary gland biopsies (MSGs). Tzioufas, A.G., Hantoumi, I., Polihronis, M., Xanthou, G., Moutsopoulos, H.M. J. Autoimmun. (1999) [Pubmed]
  26. Iodide-induced sialadenitis complicating coronary angiography. Ben-Ami, R., Zeltser, D., Herz, I., Mardi, T. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. (2002) [Pubmed]
  27. Radionuclide imaging of potassium iodide-induced sialadenitis. Goldberg, R.E., Miraldi, F. Clinical nuclear medicine. (1987) [Pubmed]
  28. Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer--a prospective,randomized, placebo-controlled, double-blind study. Grötz, K.A., Wüstenberg, P., Kohnen, R., Al-Nawas, B., Henneicke-von Zepelin, H.H., Bockisch, A., Kutzner, J., Naser-Hijazi, B., Belz, G.G., Wagner, W. The British journal of oral & maxillofacial surgery. (2001) [Pubmed]
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