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Malla, A. et al.

Ashok Malla, Norbert Schmitz, Ross Norman, Suzanne Archie, Deborah Windell, Paul Roy, Robert B. Zipursky,

A multisite Canadian study of outcome of first-episode psychosis treated in publicly funded early intervention services.

OBJECTIVE: The aim of this study was to determine 1-year symptomatic outcome and its predictors in patients with FEP treated at 3 different publicly funded sites. METHOD: We evaluated FEP patients (n = 172) treated in specialized programs in 2 medium-sized centres and 1 large urban centre with an identical protocol for demographic variables, diagnosis, and duration of untreated psychosis (DUP) at entry, and positive, negative, and general psychopathology symptoms at entry, 6 months, and 1 year. We used a mixed model analysis of variance, with time and centre and interaction between time and centre as fixed effects and sex and DUP as covariates, to analyze data. RESULTS: A significant effect of time and time x centre interaction on positive, negative, and general symptom outcome was shown after controlling for ethnicity, education, and diagnosis. Patients showed significantly better outcome on all dimensions of symptoms in the 2 medium-sized centres, compared with the 1 large urban centre. Sex had a significant effect on negative and general symptoms, while DUP had no effect on any outcome measure. CONCLUSIONS: Similarly enriched EI services may produce different outcomes, even within a relatively homogeneous mental health system.[1]

References

A multisite Canadian study of outcome of first-episode psychosis treated in publicly funded early intervention services. Malla, A., Schmitz, N., Norman, R., Archie, S., Windell, D., Roy, P., Zipursky, R.B. Can. J. Psychiatry (2007) [Pubmed]

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