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Palozza, P. et al.

Paola Palozza, Eugenio Barone, Cesare Mancuso, Nevio Picci,

The protective role of carotenoids against 7-keto-cholesterol formation in solution.

The antioxidant activity of beta-carotene and oxygenated carotenoids lutein, canthaxanthin, and astaxanthin was investigated during spontaneous and peroxyl-radical-induced cholesterol oxidation. Cholesterol oxidation, measured as generation of 7-keto-cholesterol (7-KC), was evaluated in a heterogeneous solution with cholesterol, AAPH, and carotenoids solubilized in tetrahydrofuran and in water, and in a homogeneous solution of chlorobenzene, with AIBN as a prooxidant. The formation of 7-KC was dependent on temperature and on cholesterol and prooxidant concentrations. All the carotenoids tested, exhibited significant antioxidant activity by inhibiting spontaneous, AAPH- and AIBN-induced formation of 7-KC, although the overall order of efficacy of these compounds was astaxanthin > canthaxanthin > lutein = beta-carotene. The finding that carotenoids exert protective effects on spontaneous and free radical-induced cholesterol oxidation may have important beneficial effects on human health, by limiting the formation of atheroma and by inhibiting cholesterol oxidation in food processing or storage.[1]

References

The protective role of carotenoids against 7-keto-cholesterol formation in solution. Palozza, P., Barone, E., Mancuso, C., Picci, N. Mol. Cell. Biochem. (2008) [Pubmed]

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