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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Splenic peliosis in a patient with aplastic anemia during danazol therapy.

We experienced a case of danazol-induced splenic peliosis. A 42-year-old woman had taken danazol for refractory aplastic anemia for 2 years. Her anemia gradually became aggravated, and the patient complained of intermittent left upper-abdominal pain. Because computed tomography scanning showed multiple blood-filled cavities in the enlarged spleen without intraperitoneal hemorrhage, a splenectomy was emergently performed. This report is the first of a case of splenic peliosis developing during danazol therapy for aplastic anemia. The possible association between the administration of anabolic steroids or danazol and the development of peliosis is discussed.[1]

References

  1. Splenic peliosis in a patient with aplastic anemia during danazol therapy. Arai, S., Asai, T., Uozaki, H., Hangaishi, A., Kanda, Y., Motokura, T., Chiba, S., Kurokawa, M. Int. J. Hematol. (2007) [Pubmed]
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