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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hemorrhage


Psychiatry related information on Hemorrhage


High impact information on Hemorrhage


Chemical compound and disease context of Hemorrhage


Biological context of Hemorrhage


Anatomical context of Hemorrhage

  • Bleeding occurred frequently in the absence of abnormalities of clotting tests, suggesting that hemorrhage in amyloidosis is most often due to amyloid infiltration of blood vessels [25].
  • While it may seem obvious that brisk elevations in circulating levels of vasopressin in response to hemorrhage, or of oxytocin in response to suckling, must of necessity arise from magnocellular neurosecretory neurons in the hypothalamus, the central pathways mediating these reflexes have, until quite recently, remained elusive [26].
  • These characteristics indicate that gp49B-/- mice are exquisitely sensitive to a local Shwartzman reaction (LSR) after a single i.d. injection of LPS, whereas in the classic LSR, a second exposure is required for increased beta2 integrin function, intravascular neutrophil aggregation, formation of occlusive thrombi, and hemorrhage [27].
  • We found that neuronal overexpression of human E693Q APP in mice (APPDutch mice) caused extensive CAA, smooth muscle cell degeneration, hemorrhages and neuroinflammation [28].
  • In this model, ICAM-1-mediated protection against SEB lethality correlates with a decrease in the systemic release of inflammatory cytokines, as well as with prevention of extensive hepatocyte necrosis and hemorrhage [29].

Gene context of Hemorrhage

  • The combined loss of Hey1 and Hey2, however, results in embryonic death after embryonic day 9.5 (E9.5) with a global lack of vascular remodeling and massive hemorrhage [30].
  • These results demonstrate that hemorrhage initially increases pulmonary cytokine expression through alpha- but not beta-adrenergic stimulation, and suggest that such alpha-adrenergic-mediated effects occur through activation of the transcriptional regulatory factor NF-kappaB [31].
  • The full coding sequence of a variant angiopoietin-2 (Ang2) cDNA was obtained from HCC specimens, and the biologic consequences of overexpression on tumor formation and hemorrhage were determined in an animal model system [32].
  • Edg1(-/-) mice exhibited embryonic hemorrhage leading to intrauterine death between E12.5 and E14 [33].
  • Also, ectopic expression of epidermal K14 in mouse liver results in chronic hepatitis, and disruption of mouse K8 leads to embryo lethality with extensive liver hemorrhage [34].
  • By comparing TNF-alpha(-/-) to IgH(-/-), C5(-/-), and wild-type mice, we found that TNF-alpha was important for the development of hemorrhage [35].

Analytical, diagnostic and therapeutic context of Hemorrhage


  1. Controlled trial of propranolol for the prevention of recurrent variceal hemorrhage in patients with cirrhosis. Burroughs, A.K., Jenkins, W.J., Sherlock, S., Dunk, A., Walt, R.P., Osuafor, T.O., Mackie, S., Dick, R. N. Engl. J. Med. (1983) [Pubmed]
  2. Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation. Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators. Ezekowitz, M.D., Bridgers, S.L., James, K.E., Carliner, N.H., Colling, C.L., Gornick, C.C., Krause-Steinrauf, H., Kurtzke, J.F., Nazarian, S.M., Radford, M.J. N. Engl. J. Med. (1992) [Pubmed]
  3. Different intensities of oral anticoagulant therapy in the treatment of proximal-vein thrombosis. Hull, R., Hirsh, J., Jay, R., Carter, C., England, C., Gent, M., Turpie, A.G., McLoughlin, D., Dodd, P., Thomas, M., Raskob, G., Ockelford, P. N. Engl. J. Med. (1982) [Pubmed]
  4. Heparin use as a risk factor for intraventricular hemorrhage in low-birth-weight infants. Lesko, S.M., Mitchell, A.A., Epstein, M.F., Louik, C., Giacoia, G.P., Shapiro, S. N. Engl. J. Med. (1986) [Pubmed]
  5. A controlled study of ranitidine for the prevention of recurrent hemorrhage from duodenal ulcer. Jensen, D.M., Cheng, S., Kovacs, T.O., Randall, G., Jensen, M.E., Reedy, T., Frankl, H., Machicado, G., Smith, J., Silpa, M. N. Engl. J. Med. (1994) [Pubmed]
  6. Effects of increases in plasma vasopressin concentration on plasma renin activity, blood pressure, heart rate, and plasma corticosteroid concentration in conscious dogs. Malayan, S.A., Ramsay, D.J., Keil, L.C., Reid, I.A. Endocrinology (1980) [Pubmed]
  7. Differences between vascular and plaque core amyloid in Alzheimer's disease. Prelli, F., Castaño, E., Glenner, G.G., Frangione, B. J. Neurochem. (1988) [Pubmed]
  8. Cortical petechial hemorrhage, leukoencephalopathy, and subacute dementia associated with seizures due to cerebral amyloid angiopathy. Silbert, P.L., Bartleson, J.D., Miller, G.M., Parisi, J.E., Goldman, M.S., Meyer, F.B. Mayo Clin. Proc. (1995) [Pubmed]
  9. Antenatal drugs affecting vitamin K status of the fetus and the newborn. Astedt, B. Semin. Thromb. Hemost. (1995) [Pubmed]
  10. The effects of hemorrhage and trauma on interleukin 2 production. Abraham, E., Regan, R.F. Archives of surgery (Chicago, Ill. : 1960) (1985) [Pubmed]
  11. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. Mohr, J.P., Thompson, J.L., Lazar, R.M., Levin, B., Sacco, R.L., Furie, K.L., Kistler, J.P., Albers, G.W., Pettigrew, L.C., Adams, H.P., Jackson, C.M., Pullicino, P. N. Engl. J. Med. (2001) [Pubmed]
  12. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Bush, T.G., Savidge, T.C., Freeman, T.C., Cox, H.J., Campbell, E.A., Mucke, L., Johnson, M.H., Sofroniew, M.V. Cell (1998) [Pubmed]
  13. Skeletal and CNS defects in Presenilin-1-deficient mice. Shen, J., Bronson, R.T., Chen, D.F., Xia, W., Selkoe, D.J., Tonegawa, S. Cell (1997) [Pubmed]
  14. Propranolol in the prevention of first upper gastrointestinal tract hemorrhage in patients with cirrhosis of the liver and esophageal varices. Pascal, J.P., Cales, P. N. Engl. J. Med. (1987) [Pubmed]
  15. Detection of intrapulmonary hemorrhage with carbon monoxide uptake. Application in goodpasture's syndrome. Ewan, P.W., Jones, H.A., Rhodes, C.G., Hughes, J.M. N. Engl. J. Med. (1976) [Pubmed]
  16. Regional infusion of dopamine for traumatic hemorrhage. Mud, H.J., Bruining, H.A. N. Engl. J. Med. (1980) [Pubmed]
  17. Effects of dexamethasone in primary supratentorial intracerebral hemorrhage. Poungvarin, N., Bhoopat, W., Viriyavejakul, A., Rodprasert, P., Buranasiri, P., Sukondhabhant, S., Hensley, M.J., Strom, B.L. N. Engl. J. Med. (1987) [Pubmed]
  18. Hemodialysis using prostacyclin instead of heparin as the sole antithrombotic agent. Zusman, R.M., Rubin, R.H., Cato, A.E., Cocchetto, D.M., Crow, J.W., Tolkoff-Rubin, N. N. Engl. J. Med. (1981) [Pubmed]
  19. Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats. Wu, R., Dong, W., Zhou, M., Simms, H.H., Marini, C.P., Ravikumar, T.S., Wang, P. Crit. Care Med. (2007) [Pubmed]
  20. Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury. Yang, Z.Y., Duckers, H.J., Sullivan, N.J., Sanchez, A., Nabel, E.G., Nabel, G.J. Nat. Med. (2000) [Pubmed]
  21. Management of the patient with hemorrhaging esophageal varices. Cello, J.P., Crass, R.A., Grendell, J.H., Trunkey, D.D. JAMA (1986) [Pubmed]
  22. Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis. Eddleston, M., de la Torre, J.C., Oldstone, M.B., Loskutoff, D.J., Edgington, T.S., Mackman, N. J. Clin. Invest. (1993) [Pubmed]
  23. Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. Mulligan, M.S., Varani, J., Dame, M.K., Lane, C.L., Smith, C.W., Anderson, D.C., Ward, P.A. J. Clin. Invest. (1991) [Pubmed]
  24. Effects of ergothioneine, cysteine, and glutathione on nitrosation of secondary amines under physiologic conditions. Kunisaki, N., Hayashi, M. J. Natl. Cancer Inst. (1980) [Pubmed]
  25. Bleeding manifestations in 100 patients with amyloidosis. Yood, R.A., Skinner, M., Rubinow, A., Talarico, L., Cohen, A.S. JAMA (1983) [Pubmed]
  26. Reflex control of magnocellular vasopressin and oxytocin secretion. Cunningham, E.T., Sawchenko, P.E. Trends Neurosci. (1991) [Pubmed]
  27. Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils. Zhou, J.S., Friend, D.S., Feldweg, A.M., Daheshia, M., Li, L., Austen, K.F., Katz, H.R. J. Exp. Med. (2003) [Pubmed]
  28. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Herzig, M.C., Winkler, D.T., Burgermeister, P., Pfeifer, M., Kohler, E., Schmidt, S.D., Danner, S., Abramowski, D., Stürchler-Pierrat, C., Bürki, K., van Duinen, S.G., Maat-Schieman, M.L., Staufenbiel, M., Mathews, P.M., Jucker, M. Nat. Neurosci. (2004) [Pubmed]
  29. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. Xu, H., Gonzalo, J.A., St Pierre, Y., Williams, I.R., Kupper, T.S., Cotran, R.S., Springer, T.A., Gutierrez-Ramos, J.C. J. Exp. Med. (1994) [Pubmed]
  30. The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Fischer, A., Schumacher, N., Maier, M., Sendtner, M., Gessler, M. Genes Dev. (2004) [Pubmed]
  31. Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kappaB regulation and cytokine expression. Le Tulzo, Y., Shenkar, R., Kaneko, D., Moine, P., Fantuzzi, G., Dinarello, C.A., Abraham, E. J. Clin. Invest. (1997) [Pubmed]
  32. Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. Tanaka, S., Mori, M., Sakamoto, Y., Makuuchi, M., Sugimachi, K., Wands, J.R. J. Clin. Invest. (1999) [Pubmed]
  33. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C.X., Hobson, J.P., Rosenfeldt, H.M., Nava, V.E., Chae, S.S., Lee, M.J., Liu, C.H., Hla, T., Spiegel, S., Proia, R.L. J. Clin. Invest. (2000) [Pubmed]
  34. Mutation of human keratin 18 in association with cryptogenic cirrhosis. Ku, N.O., Wright, T.L., Terrault, N.A., Gish, R., Omary, M.B. J. Clin. Invest. (1997) [Pubmed]
  35. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. Chen, H.C., Hofman, F.M., Kung, J.T., Lin, Y.D., Wu-Hsieh, B.A. J. Virol. (2007) [Pubmed]
  36. The role of injection sclerotherapy in the emergency and definitive management of bleeding esophageal varices. Allison, J.G. JAMA (1983) [Pubmed]
  37. A controlled comparison of continuous intraarterial and intravenous infusions of vasopressin in hemorrhage from esophageal varices. Chojkier, M., Groszmann, R.J., Atterbury, C.E., Bar-Meir, S., Blei, A.T., Frankel, J., Glickman, M.G., Kniaz, J.L., Schade, R., Taggart, G.J., Conn, H.O. Gastroenterology (1979) [Pubmed]
  38. Primary prophylaxis of variceal hemorrhage: a randomized controlled trial comparing band ligation, propranolol, and isosorbide mononitrate. Lui, H.F., Stanley, A.J., Forrest, E.H., Jalan, R., Hislop, W.S., Mills, P.R., Finlayson, N.D., Macgilchrist, A.J., Hayes, P.C. Gastroenterology (2002) [Pubmed]
  39. A meta-analysis of somatostatin versus vasopressin in the management of acute esophageal variceal hemorrhage. Imperiale, T.F., Teran, J.C., McCullough, A.J. Gastroenterology (1995) [Pubmed]
  40. Endoscopic treatment of Dieulafoy's disease. Pointner, R., Schwab, G., Königsrainer, A., Dietze, O. Gastroenterology (1988) [Pubmed]
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