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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Splenectomy


Psychiatry related information on Splenectomy


High impact information on Splenectomy


Chemical compound and disease context of Splenectomy


Biological context of Splenectomy


Anatomical context of Splenectomy


Associations of Splenectomy with chemical compounds


Gene context of Splenectomy

  • We conclude that splenectomy had a beneficial effect owing to an increase in NK cells and an associated increase in TGF-beta production [30].
  • In addition, it is possible that splenectomy could be an effective treatment option for some patients with severe, congenital TTP [31].
  • To our knowledge, our patient is the first case of portal, mesenteric, and splenic vein thromboses after splenectomy in a patient with CML variant with thrombocythemic onset successfully treated with antegrade intraarterial thrombolytic therapy followed by anticoagulant therapies [32].
  • RESULTS: Pre- and postoperative serum leptin concentrations did not differ significantly in rats with partial hepatectomy (5.1 +/- 0.4 versus 4.2 +/- 1.1 microg/L), splenectomy (6.1 +/- 0.4 versus 5.0 +/- 0.6 microg/L), or unilateral nephrectomy (4.1 +/- 0.7 versus 5.0 +/- 1.3 microg/L) [33].
  • Thrombospondin plasma levels (77.1 +/- 20.1 ng/ml) in 14 patients having undergone splenectomy were significantly increased (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)[34]

Analytical, diagnostic and therapeutic context of Splenectomy


  1. Remissions in hairy-cell leukemia with pentostatin (2'-deoxycoformycin). Spiers, A.S., Moore, D., Cassileth, P.A., Harrington, D.P., Cummings, F.J., Neiman, R.S., Bennett, J.M., O'Connell, M.J. N. Engl. J. Med. (1987) [Pubmed]
  2. Increased circulating levels of transcobalamin ii in gaucher's disease. Gilbert, H.S., Weinreb, N. N. Engl. J. Med. (1976) [Pubmed]
  3. Elevated platelet-associated IgG in thrombotic thrombocytopenic purpura. Morrison, J., McMillan, R. JAMA (1977) [Pubmed]
  4. Clinical trials in hairy cell leukemia. Current status and future directions. Cheson, B.D., Martin, A. Ann. Intern. Med. (1987) [Pubmed]
  5. Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Levin, J., Peng, J.P., Baker, G.R., Villeval, J.L., Lecine, P., Burstein, S.A., Shivdasani, R.A. Blood (1999) [Pubmed]
  6. Stress differentially induces cationic amino acid transporter gene expression. Kakuda, D.K., Finley, K.D., Maruyama, M., MacLeod, C.L. Biochim. Biophys. Acta (1998) [Pubmed]
  7. Mechanisms of response to treatment in autoimmune thrombocytopenic purpura. Gernsheimer, T., Stratton, J., Ballem, P.J., Slichter, S.J. N. Engl. J. Med. (1989) [Pubmed]
  8. Reticuloendothelial clearance in cystic fibrosis and other inflammatory lung diseases. Mantzouranis, E.C., Rosen, F.S., Colten, H.R. N. Engl. J. Med. (1988) [Pubmed]
  9. Splenectomy in the Wiskott-Aldrich syndrome. Nathan, D.G. N. Engl. J. Med. (1980) [Pubmed]
  10. Human babesiosis. Clinical and therapeutic considerations. Gombert, M.E., Goldstein, E.J., Benach, J.L., Tenenbaum, M.J., Grunwaldt, E., Kaplan, M.H., Eveland, L.K. JAMA (1982) [Pubmed]
  11. High-dose methotrexate with leucovorin rescue: effectiveness in relapsed hairy cell leukemia. Joosten, P., Hagenbeek, A., Löwenberg, B., Sizoo, W. Blood (1985) [Pubmed]
  12. Alpha-2 interferon therapy of hairy-cell leukemia: a multicenter study of 64 patients. Golomb, H.M., Jacobs, A., Fefer, A., Ozer, H., Thompson, J., Portlock, C., Ratain, M., Golde, D., Vardiman, J., Burke, J.S. J. Clin. Oncol. (1986) [Pubmed]
  13. Multiple autoimmune manifestations in a splenectomized subject with HLA-B8. Kleiner-Baumgarten, A., Schlaeffer, F., Keynan, A. Arch. Intern. Med. (1983) [Pubmed]
  14. Chronic immunologic thrombocytopenic purpura: results of cyclophosphamide therapy before splenectomy. Srichaijul, T., Boonpucknavig, S., Archararit, N., Chaisiri-pumkeeree, W. Arch. Intern. Med. (1980) [Pubmed]
  15. High-dose intravenous gamma-immunoglobulin infusion in the treatment of thrombotic thrombocytopenic purpura. Finn, N.G., Wang, J.C., Hong, K.J. Arch. Intern. Med. (1987) [Pubmed]
  16. Effect of chronic rapid ventricular pacing on total vascular capacitance. Ogilvie, R.I., Zborowska-Sluis, D. Circulation (1992) [Pubmed]
  17. The effect of therapy on platelet-associated autoantibody in chronic immune thrombocytopenic purpura. Fujisawa, K., Tani, P., Piro, L., McMillan, R. Blood (1993) [Pubmed]
  18. Hypomethylation of DNA derived from purified human erythroid cells correlates with gene activity of the beta-globin cluster. Oppenheim, A., Katzir, Y., Fibach, E., Goldfarb, A., Rachmilewitz, E. Blood (1985) [Pubmed]
  19. BCL1, a murine model of prolymphocytic leukemia. I. Effect of splenectomy on growth kinetics and organ distribution. Muirhead, M.J., Isakson, P.C., Krolick, K.A., Uhr, J.W., Vitetta, E.S. Am. J. Pathol. (1981) [Pubmed]
  20. Studies of lymphoproliferation in MRL-lpr/lpr mice. Smathers, P.A., Santoro, T.J., Chused, T.M., Reeves, J.P., Steinberg, A.D. J. Immunol. (1984) [Pubmed]
  21. Influence of continuous interleukin-2 administration via the portal vein on liver regeneration following partial hepatectomy in rats. Wadamori, K., Oka, M., Tokuda, N., Fujikura, Y., Hazama, S., Fukumoto, T., Suzuki, T. Hepatology (1996) [Pubmed]
  22. Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats. Like, A.A., Weringer, E.J., Holdash, A., McGill, P., Atkinson, D., Rossini, A.A. J. Immunol. (1985) [Pubmed]
  23. Association of natural killer cell depletion with induction of mixed chimerism and allograft tolerance in non-human primates. Kawai, T., Wee, S.L., Bazin, H., Latinne, D., Phelan, J., Boskovic, S., Ko, D.S., Hong, H.Z., Mauiyyedi, S., Nadazdin, O., Abrahamian, G., Preffer, F., Colvin, R.B., Sachs, D.H., Cosimi, A.B. Transplantation (2000) [Pubmed]
  24. Splenic implants: evaluation with radionuclide methods. Abu-Nema, T., Nawaz, K., Sadek, S., Ayyash, K., Tibblin, S., Al-Mohannadi, S., Abdel-Dayem, H.M. Radiology. (1987) [Pubmed]
  25. The effect of partial splenectomy on platelet production in mice. Bessler, H., Notti, I., Djaldetti, M. Thromb. Haemost. (1981) [Pubmed]
  26. Hereditary thrombocytopenia, deafness, and renal disease. Eckstein, J.D., Filip, D.J., Watts, J.C. Ann. Intern. Med. (1975) [Pubmed]
  27. Intermittent cyclophosphamide for the treatment of autoimmune thrombocytopenia in systemic lupus erythematosus. Boumpas, D.T., Barez, S., Klippel, J.H., Balow, J.E. Ann. Intern. Med. (1990) [Pubmed]
  28. Splenectomy done during hematologic remission to prevent relapse in patients with thrombotic thrombocytopenic purpura. Crowther, M.A., Heddle, N., Hayward, C.P., Warkentin, T., Kelton, J.G. Ann. Intern. Med. (1996) [Pubmed]
  29. Encapsulation of doxorubicin in liver-targeted erythrocytes increases the therapeutic index of the drug in a murine metastatic model. Zocchi, E., Tonetti, M., Polvani, C., Guida, L., Benatti, U., De Flora, A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  30. Th1 and Th2 cytokines in a patient with Evans' syndrome and profound lymphopenia. Karakantza, M., Mouzaki, A., Theodoropoulou, M., Bussel, J.B., Maniatis, A. Br. J. Haematol. (2000) [Pubmed]
  31. Dissociation between the level of von Willebrand factor-cleaving protease activity and disease in a patient with congenital thrombotic thrombocytopenic purpura. Snider, C.E., Moore, J.C., Warkentin, T.E., Finch, C.N., Hayward, C.P., Kelton, J.G. Am. J. Hematol. (2004) [Pubmed]
  32. Portal, mesenteric, and splenic vein thromboses after splenectomy in a patient with chronic myeloid leukemia variant with thrombocythemic onset. Lee, J.J., Kim, H.J., Chung, I.J., Park, M.R., Seo, K.S., Jeong, Y.Y., Kim, J.K. Am. J. Hematol. (1999) [Pubmed]
  33. Serum leptin concentrations after surgery in young rats. Zivna, H., Zivny, P., Palicka, V. Nutrition (Burbank, Los Angeles County, Calif.) (2002) [Pubmed]
  34. Plasma thrombospondin in patients with chronic renal failure, liver disease and splenectomy. Trzeciak, M.C., McGregor, J., Renaux, J.L., Ville, D., Berruyer, M., Dawes, J., Dechavanne, M. Thromb. Res. (1985) [Pubmed]
  35. Acquired deficiency of von Willebrand factor-cleaving protease in a patient with thrombotic thrombocytopenic purpura. Furlan, M., Robles, R., Solenthaler, M., Lämmle, B. Blood (1998) [Pubmed]
  36. Rearrangement of both immunoglobulin and T-cell receptor genes in a prolymphocytic variant of hairy cell leukemia patient resistant to interferon-alpha. Giardina, S.L., Young, H.A., Faltynek, C.R., Jaffe, E.S., Clark, J.W., Steis, R.G., Urba, W.J., Mathieson, B.J., Gralnick, H., Lawrence, J. Blood (1988) [Pubmed]
  37. Effects of neonatal thymectomy and splenectomy on survival and regulation of autoantibody formation in NZB/NZW F1 mice. Roubinian, J.R., Papoian, R., Talal, N. J. Immunol. (1977) [Pubmed]
  38. Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine adjuvant immunotherapy for splenic hemangiosarcoma in the dog: a randomized multi-institutional clinical trial. Vail, D.M., MacEwen, E.G., Kurzman, I.D., Dubielzig, R.R., Helfand, S.C., Kisseberth, W.C., London, C.A., Obradovich, J.E., Madewell, B.R., Rodriguez, C.O. Clin. Cancer Res. (1995) [Pubmed]
  39. Development of a mouse mammary tumor virus-negative mouse strain: a new system for the study of mammary carcinogenesis. Cohen, J.C., Traina, V.L., Breznik, T., Gardner, M. J. Virol. (1982) [Pubmed]
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