Disease relevance of Anemia, Aplastic

• In congenital defects of granulocyte production or in acquired disorders such as idiopathic neutropenia or aplastic anemia, CSF administration can lead to recovery of functioning granulocytes [1].
• Myelodysplasia and leukemia after treatment of aplastic anemia with G-CSF [2].
• Psoas abscess localization by gallium scan in aplastic anemia [3].
• SETTING: Study of the Late Effects Working Party with 45 transplantation centers cooperating in the European Cooperative Group for Blood and Marrow Transplantation. PATIENTS: 1036 consecutive patients who underwent transplantation for leukemia, lymphoma, inborn diseases of the hematopoietic and immune systems, or severe aplastic anemia [4].
• Twenty-four patients, including two with aplastic anemia and 22 with malignancy, underwent marrow transplantation after preparation with mechlorethamine, 0.3 to 2.0 mg/kg body weight [5].

Psychiatry related information on Anemia, Aplastic

• Bone marrow transplantation for transfused patients with severe aplastic anemia using cyclophosphamide and total lymphoid irradiation as conditioning therapy: long-term follow-up from a single center [6].

High impact information on Anemia, Aplastic

• Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. The German Aplastic Anemia Study Group [7].
• Cyclosporine and recombinant granulocyte colony-stimulating factor in severe aplastic anemia [8].
• More about acyclovir and aplastic anemia [9].
• Aplastic anemia due to tocainide [10].
• Tac antigen expression, another surface marker of lymphocyte activation, was increased on suppressor lymphocytes in all five patients examined (patients with aplastic anemia, 31 +/- 17 per cent; normal subjects, 0.7 +/- 0.24; patients given multiple transfusions, 2.3 +/- 1.2) [11].

Chemical compound and disease context of Anemia, Aplastic

• Cyclophosphamide for aplastic anemia [12].
• Cyclosporine in refractory severe aplastic anemia [13].
• Ocular chloramphenicol and aplastic anemia [14].
• Bolus methylprednisolone in severe aplastic anemia [15].
• Lithium therapy of aplastic anemia [16].

Biological context of Anemia, Aplastic

• Graft rejection has been a problem after marrow grafts for patients with aplastic anemia who were conditioned with cyclophosphamide (CY) [17].
• These findings suggest that telomerase-based therapies could be useful prophylactic agents in FA aplastic anemia by preserving their telomere reserve in the context of the disease [18].
• Individuals with GSTM1 and GSTT1 gene deletions may have greater susceptibility to aplastic anemia [19].
• Fanconi's anemia (FA) is an autosomal recessive condition in which greater than 90% of the homozygotes develop aplastic anemia [20].
• The temporal association between aplastic anemia and the onset of thrombotic graft microangiopathy, isolation of the viral genome in renal specimens, seroconversion, and endothelial tropism of the virus suggests that B19 could be the etiologic agent of thrombotic microangiopathy in these cases [21].

Anatomical context of Anemia, Aplastic

• When lymphocytes of patients with aplastic anemia were cocultured with normal bone marrow, only the Tac+ cell fraction showed hematopoietic suppressor activity [11].
• A cytotoxic T cell (CT) lines grown as a population (CT line) was initiated from the peripheral blood lympocytes (PBL) of a female aplastic anemia patient who was known to express CT that were able to lyse HLA-A2-positive male cells [22].
• The AM-IgG fraction was able to suppress the ability of both aplastic anemia serum and purified Meg-CSF to promote megakaryocyte colony formation [23].
• High-dose cyclophosphamide, without stem cell rescue, has been used successfully to treat aplastic anemia and other autoimmune disorders [24].
• Monocyte dysfunction and decreased IL-1 production have been shown to be involved in aplastic anemia in humans [25].

Gene context of Anemia, Aplastic

• Lymphokine abnormalities in aplastic anemia: implications for the mechanism of action of antithymocyte globulin [26].
• Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit [27].
• Mutations in TERC, encoding the RNA component of telomerase, have been found in autosomal dominant dyskeratosis congenita (DC) and aplastic anemia (AA) [28].
• The potential utility of c-mpl ligands for treatment of myelodysplastic syndromes, aplastic anemias, or in HIV infection, will have to be evaluated in the future [29].
• From the standard curve, the probable levels of G-CSF were calculated as follows: approximately 200 pg/ml with infection, 130-220 pg/ml with aplastic anemia, 150 and 200 pg/ml with AMMoL, and 1120 and 1200 pg/ml with idiopathic neutropenia [30].

Analytical, diagnostic and therapeutic context of Anemia, Aplastic

• One hundred thirty patients with severe aplastic anemia were conditioned with cyclophosphamide for transplantation of marrow from HLA-identical siblings [31].
• Intensive immunosuppression with antithymocyte globulin and cyclosporine as treatment for severe acquired aplastic anemia [32].
• A preparative regimen, consisting of total lymphoid irradiation and cyclophosphamide, was utilized in 40 patients with severe aplastic anemia undergoing allogeneic marrow transplantation [33].
• Cyclophosphamide and low-dose total body irradiation is an effective conditioning regimen in patients with aplastic anemia [34].
• Lymphokine overproduction in severe aplastic anemia is not related to blood transfusions [35].

References