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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
The influence of corticosteroids on the release of novel biomarkers in human endotoxemia.
OBJECTIVE: Sepsisintervention studies need better patient stratification methods, and one way to realize this is the introduction of stable biomarkers.A set of recently developed novel biomarkers, based upon precursor-fragments of short-lived hormones, was previously shown to be increased during sepsis.However, it is not known whether these biomarkers are influenced by sepsis intervention strategies.Therefore we investigated the markers in a model of human endotoxemia intervened by increasing doses of prednisolone.DESIGN AND SETTING: Prospective, open-label study in a specialized clinical research unit of a university hospital.SUBJECTS: Thirty-two healthy male volunteers.INTERVENTIONS: Subjects received prednisolone orally at doses of 0, 3, 10 or 30 mg (n=8 per group) at 2 h before intravenous injection of Escherichia colilipopolysaccharide (LPS) (4 ng/kg).Blood samples were drawn during 24 h after LPS injection.MEASUREMENTS AND RESULTS: LPS injection caused an increase in levels of midregional pro-adrenomedullin (MR-proADM), midregional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-arginine-vasopressin (CT-proAVP) and procalcitonin (PCT).Prednisolone caused a dose dependent inhibition of MR-proADM, MR-proANP and CT-proAVP levels.CONCLUSIONS: These results show that a set of novel, highly stable sepsis biomarkers was increased during human endotoxemia and was dose-dependently inhibited by corticosteroid pre-treatment.[1]
